The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome
Elevated levels of oxidative nucleic acid modifications have been proposed to be associated with some of the clinical characteristics of Down syndrome. Oral intake of coenzyme Q10 (CoQ10) improves oxidative status and shows a tendency towards protective effect on DNA oxidation in certain age groups of children with Down syndrome. Here, we demonstrate that long-term (i.e. 4 years) treatment with CoQ10 (ubiquinone) at the dosage of 4 mg/kg/day does not affect whole body DNA and RNA oxidation.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Emil List Larsen, Lucia Padella, Helle Kirstine M ørup Bergholdt, Trine Henriksen, Lucia Santoro, Orazio Gabrielli, Henrik Enghusen Poulsen, Gian Paolo Littarru, Patrick Orlando, Luca Tiano Tags: Negative results Source Type: research