GC –MS detection of plant pigments and metabolites in Roman Julio-Claudian wall paintings
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Angelo Gismondi, Lorena Canuti, Giulia Rocco, Marcella Pisani, Alessandra Ghelli, Margherita Bonanno, Antonella Canini For the first time, plant pigments were detected in Roman frescoes. Indeed, only sporadic papers proved the application of natural hues in ancient paintings and none of them relative to Roman art. Therefore, eight differently coloured fragments of Julio-Claudian wall paintings, collected from Terme degli Stucchi Dipinti archaeological site (Rome, Italy), were subjected to GC–MS analysis, obtaining detailed chemical profiles. Vegetal dyes (ie. Indigotin, Neronine, Alizarin) or colourless metabolites ascribable to plant species (ie. Basella rubra, Sesanum radiatum, Lamium purpureum) were detected. Plant waxes, oils (ie. Brassicaceae) and resins (ie. Pinaceae) were found to be preferred as binders or protective coatings instead of animal glues (ie. collagen, egg). Several natural molecules, typically associated to plant organisms (ie. Lamiaceae and Citrus species), were also identified. These data suggest the predominant role of plant extracts in ancient art and increase the knowledge about organic materials of Roman frescoes, facilitating modern restorers’ activities. Graphical abstract
Conclusions: Results reveals that developed nitrendipine nanoemulsion gel overcomes the limitation of low penetration and accentuate permeation through albino Wistar rat skin. It was concluded that nanoemulsion gel could be utilized as a potential carrier for transdermal delivery of nitrendipine. PMID: 31976777 [PubMed - as supplied by publisher]
Authors: Rezaie Shirmard L, Ghofrani M, Bahari Javan N, Bayrami S, Tavassoli A, Rezaie A, Amini M, Kebriaee-Zadeh A, Rouini MR, Dinarvand R, Rafiee-Tehrani M, Dorkoosh FA Abstract Uncontrolled distribution of nanoparticles (NPs) within the body can significantly decrease the efficiency of drug therapy and is considered among the main restrictions of NPs application. The aim of this study was to develop a depot combination delivery system (CDS) containing fingolimod loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) NPs dispersed into a matrix of oleic acid-grafted-aminated alginate (OA-g-AAlg) to minimize ...
Authors: Yoshida T, Sako K, Kondo H Abstract High consumption of oil formulations has been reported to reduce the blood exposure of drugs like tacrolimus. Consumption of oil formulations has also been shown to inhibit T-cell production of interleukin-2 (IL-2) compared to solid dispersion formulations (SDFs). However, a large amount of oil causes gastrointestinal side effects such as diarrhea and low compliance. Here, we investigated the feasibility of reducing the amount of oil and substitution of chemically synthetized oils for natural oils in these formulations. Reducing the amount of sunflower oil increased bloo...
CONCLUSIONS: In conclusion, the potential for supersaturation in LBDDS, and the risk of precipitation, was found to be highly drug dependent. The apparent degree of supersaturation was considered a major factor impacting the ability to maintain drug supersaturation upon storage. PMID: 31975613 [PubMed - as supplied by publisher]
Authors: Mailhot Vega RB, Hoppe BS PMID: 31976780 [PubMed - as supplied by publisher]
With a second case of a deadly Chinese virus confirmed in the United States, and four cases under investigation in New York, Buffalo-area hospitals are on alert and preparing as best as they can. The novel coronavirus was first identified in Wuhan, China, in December. More than 850 cases have since been reported worldwide, with more than 40 deaths in China. Transportation has been shutdown with travel restricted for millions in that country as international officials work to contain the di sease. In…