Favism and Glucose-6-Phosphate Dehydrogenase Deficiency

New England Journal of Medicine,Volume 378, Issue 11, Page 1067-1069, March 2018.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research

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Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret MackinnonSummaryBackgroundHuman genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells&...
Source: The Lancet Haematology - Category: Hematology Source Type: research
This study investigated the protective potential of progesterone on cadmium-induced damage in Wistar rats.Adult male Wistar rats received CdCl2 once daily for 21 days. Progesterone was given 30 min. after administration of CdCl2 while 3 other groups were given distilled water, CdCl2 and progesterone alone. Blood samples were collected from the animals for the determination of liver function and antioxidant status while the liver, kidney, cerebellar and hippocampal tissues were excised and fixed in Neutral buffered formalin for histopathological studies.While Cadmium caused changes in liver function parameters which ...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
In this study, aiming at the discovery of predictive markers for tumor invasion, we performed protein profiling between LCN1-sus and LCN1-co cells using two-dimensional gel electrophoresis. Twenty-six protein spots with>1.2-fold quantitative differences between LCN1-sus and LCN1-co cells were detected. Among the identified proteins, we focused on and immunohistochemically investigated G6PD in lung cancer. G6PD expression was significantly associated with a higher pathological TNM stage (p = 0.0024), lymph node metastasis (p = 0.0187), poorer differentiation (p = 0.0046), pleural invasion (p = 0.0197), va...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
In conclusion, CO improves neuronal differentiation of SH-S5Y5 cells by stimulating the PPP and modulating the GSH system.Graphical abstract
Source: Redox Biology - Category: Biology Source Type: research
In this study, we established an anchorage independent growth model for MDA-MB-231 cells and investigated the changes in metabolism and redox homeostasis. Results showed that during detached-growth, MDA-MB-231 cells tend to generate ATP through fatty acid oxidation (FAO), instead of glycolysis. Amount of glucose was used for pentose phosphate pathway (PPP) to keep redox balance. Moreover, we discovered that a synthesized flavonoid derivative GL-V9, exhibited a potent inhibitory effect on the anchorage independent growth of TNBCs in vitro and anti-metastasis effect in vivo. In terms of the mechanism, GL-V9 could promote the...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: July 2018Source: Journal of Bioscience and Bioengineering, Volume 126, Issue 1Author(s): Kentaro Ueda, Tsubasa Nakajima, Katsunori Yoshikawa, Yoshihiro Toya, Fumio Matsuda, Hiroshi ShimizuThe role of the oxidative pentose phosphate pathway (oxPPP) in Synechocystis sp. PCC 6803 under mixotrophic conditions was investigated by 13C metabolic flux analysis. Cells were cultured under low (10 μmol m−2 s−1) and high light intensities (100 μmol m−2 s−1) in the presence of glucose. The flux of CO2 fixation by ribulose bisphosphate carboxylase/oxygenase un...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
This study evaluates the therapeutic potential of intranasal insulin (INI) in dexamethasone-induced insulin resistance in Wistar rats. In the first phase of the study, thirteen, healthy, untreated male Wistar rats were divided into 2 groups and administered either vehicle (0.9% Normal saline, 20 µl) or insulin (2 IU) intranasally to assess intranasal delivery of insulin in brain. In the second phase of experiments, to evaluate the acute effects of intranasal insulin on peripheral blood glucose, intranasal or intraperitoneal insulin was co-administered with or without dexamethasone 10 mg/kg to 26 male Wistar rats ...
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research
The objective of this study was to determine if temporal variations in tissue metal concentrations are related to biomarkers of retinoid metabolism and oxidative stress responses in juvenile yellow perch (Perca flavescens). To this end, kidney metal (Cd, Cu and Zn) concentrations were measured in fish sampled in spring and fall 2012 in four lakes representing a wide range of water and sediment metal contamination in the Rouyn-Noranda (Quebec) region. Lakes Opasatica and Hélène were considered as reference lakes while lakes Dufault and Marlon were metal-contaminated. Kidney concentrations of Cd, Cu and Zn vari...
Source: Aquatic Toxicology - Category: Toxicology Source Type: research
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Olayemi Joseph Olajide, John Oluwasegun Fatoye, Oluwakunmi Folashade Idowu, Damilola Ilekoya, Ismail Temitayo Gbadamosi, Monsurat Titi Gbadamosi, Nnaemeka Tobechukwu AsogwaAbstractMetal ions are crucial for normal neurochemical signaling and perturbations in their homeostasis have been associated with neurodegenerative processes. Hypothesizing that in vivo modulation of key neurochemical processes including metal ion regulation (by transferrin receptor-1: TfR-1) in cells can improve disease outcome, we investigated the ef...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
Publication date: June 2018Source: Molecular Genetics and Metabolism, Volume 124, Issue 2Author(s): Xinying Hong, Arun Babu Kumar, C. Ronald Scott, Michael H. GelbAbstractAll States screen for biotinidase deficiency and galactosemia, and X-linked adrenoleukodystrophy (X-ALD) has recently been added to the Recommended Uniform Screening Panel (RUSP).We sought to consolidate these tests by combining them into a single multiplex tandem mass spectrometry assay as well as to improve the current protocol for newborn screening of galactosemia.A 3 mm punch of a dried blood spot (DBS) was extracted with organic solvent for analysi...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
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