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Favism and Glucose-6-Phosphate Dehydrogenase Deficiency

New England Journal of Medicine,Volume 378, Issue 11, Page 1067-1069, March 2018.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research

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by Judith Recht, Elizabeth A. Ashley, Nicholas J. White Primaquine is the only available antimalarial drug that kills dormant liver stages ofPlasmodium vivax andPlasmodium ovale malarias and therefore prevents their relapse ( ‘radical cure’). It is also the only generally available antimalarial that rapidly sterilises matureP.falciparum gametocytes. Radical cure requires extended courses of primaquine (usually 14 days; total dose 3.5 –7 mg/kg), whereas transmissibility reduction in falciparum malaria requires a single dose (formerly 0.75 mg/kg, now a single low dose [SLD] of 0.25 mg/kg is recommended). T...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Does anybody have a mnemonic for the drugs that cause hemolysis in G6PD deficiency? I'm clueless... Thanks! Adam
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Publication date: Available online 29 March 2018 Source:Molecular Genetics and Metabolism Author(s): Xinying Hong, Arun Babu Kumar, C. Ronald Scott, Michael H. Gelb All States screen for biotinidase deficiency and galactosemia, and X-linked adrenoleukodystrophy (X-ALD) has recently been added to the Recommended Uniform Screening Panel (RUSP). We sought to consolidate these tests by combining them into a single multiplex tandem mass spectrometry assay as well as to improve the current protocol for newborn screening of galactosemia. A 3 mm punch of a dried blood spot (DBS) was extracted with organic solvent for analysis o...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
In conclusion, DEHP may induce liver and kidney damage, also result abnormalities in the trace element and mineral levels. PMID: 29654488 [PubMed - as supplied by publisher]
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
In this study, to increase the NADPH supply, the endogenous NAD+ kinase gene ppnK and glucose-6-phosphate dehydrogenase gene zwf were co-expressed with ido. The resulting strain SL01 produced 81.12 ± 5.96 mM 4-HIL, 62% higher than the ido-mere expressing strain SN02. However, the strain SL02 co-expressing exogenous NADH kinase gene POS5 with ido grew slowly and its 4-HIL production decreased by 12%, perhaps due to the lower 2-oxoglutarate (OG) level and slightly weaker membrane permeability. To increase OG availability for 4-HIL conversion, the serine/threonine protein kinase G gene pknG was deleted and replac...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
Publication date: Available online 11 April 2018 Source:Chemico-Biological Interactions Author(s): Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyp...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Abstract Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice. Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 week...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
No reports regarding the safety of thrombolysis in acute stroke patients with a G6PD deficiency have been published to date. Here we aimed to evaluate the safety of intravenous thrombolysis for G6PD-deficient stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Abstract L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion molecules. Using human U937 monocytes, this study examined the effect of GSH/G6PD...
Source: Amino Acids - Category: Biochemistry Authors: Tags: Amino Acids Source Type: research
In this study, the full-length gene of G6PD from Y. lipolytica (YlG6PD) was cloned without intron and heterogeneously expressed in E. coli. Then, YlG6PD was purified and biochemically characterized in details. Kinetic analysis showed that YlG6PD was completely dependent on NADP+ and its apparent K m for NADP+ was 33.3 μM. The optimal pH was 8.5 and the maximum activity was around 47.5 °C. Heat-inactivation profiles revealed that it remained 50% of maximal activity after incubation at 48 °C for 20 min YlG6PD activity was competitively inhibited by NADPH with a K i value of 56.04 μM. Most of the metal...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
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