Autologous Stem-Cell Transplantation for Severe Scleroderma

New England Journal of Medicine,Volume 378, Issue 11, Page 1066-1067, March 2018.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research

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This report presents a full-mouth implant-retained reconstruction in a 35-year-old male patient who had undergone alloHCT for treatment of acute myeloid leukemia and developed sclerotic cGVHD afterwards. Implant-retained prosthetics might be a practicable treatment for patients with these complications.
Source: Quintessence International - Category: Dentistry Source Type: research
Authors: Das A, Kumar A, Arrossi AV, Ghosh S, Highland KB Abstract INTRODUCTION: Interstitial lung disease (ILD) is the most common cause of mortality in systemic sclerosis; accounting for approximately 35% of deaths. Although immunosuppression is currently opted as first line therapy for scleroderma-related ILD (SSc-ILD), the benefits from it remain modest with concerns for systemic toxicity from long term use. Areas covered: We review the important facets in monitoring a patient with SSc-ILD, including recognizing various patterns of ILD, identifying those at risk for disease progression and discuss the strength ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the app...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionsThis first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Systemic sclerosis (SSc) is a heterogeneous disease with a pervasive impact on quality of life and high rates of associated morbidity and mortality. Three randomized controlled trial (RCT) and a retrospective study have suggested that autologous stem cell transplantation (ASCT) is an effective treatment modality for this devastating disease [1 –4]. We have previously performed a meta-analysis to provide a pooled estimate of trials comparing ASCT to standard treatment in patients with severe SSc [5].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Systemic sclerosis (SSc) is a heterogeneous disease with a pervasive impact on quality of life and high rates of associated morbidity and mortality. Three randomized controlled trials (RCTs) and a retrospective study have suggested that autologous stem cell transplantation (ASCT) is an effective treatment modality for this devastating disease [1 –4]. We have previously performed a meta-analysis to provide a pooled estimate of trials comparing ASCT and standard treatment in patients with severe SSc [5].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
We read with interest the recent systematic review and meta-analysis of Shouval and colleagues in Biology of Blood and Marrow Transplantation 24 (2018) 937-944, [1] with the same subject matter as our own article “Autologous stem cell transplantation in systemic sclerosis: a systematic review” in Clinical and Experimental Rheumatology 2017; 35(Suppl. 106): S198-S207. [2] Using a broader search strategy than our own, Shouval et. al. [1] were only able to identify one additional retrospective analysis and one randomized controlled trial (RCT) comparing autologous hematopoietic stem cell transplantation (AHSCT) wi...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
We read with interest the recent systematic review and meta-analysis of Shouval et al. [1] Biology of Blood and Marrow Transplantation with the same subject matter as our own article, “Autologous stem cell transplantation in systemic sclerosis: a systematic review,” in Clinical and Experimental Rheumatology in 2017 [2]. Using a broader search strategy than our own, Shouval et al. [1] were only able to identify 1 additional retrospective analysis and 1 randomized controlled tr ial comparing autologous hematopoietic stem cell transplantation (AHSCT) with standard immunosuppressive therapy in patients with systemic sclerosis (SSc).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Abstract Haematopoietic stem cell transplantation was proposed as a treatment strategy just over 60 years ago. Owing to great advances in the field, haematopoietic stem cell transplantation has become an established method for the treatment of many haemato-oncological, immunological and hereditary conditions with the potential of cure. The number of haematopoietic stem cell transplants performed worldwide reached one million by 2012. This review provides an overview of autologous and allogeneic haematopoietic stem cell transplantation including disease indications, the individual steps of the procedure and outcome...
Source: British Journal of Hospital Medicine - Category: Internal Medicine Authors: Tags: Br J Hosp Med (Lond) Source Type: research
Background. Diffuse cutaneous systemic sclerosis (SSc) is a multi-system chronically progressive and debilitating autoimmune connective tissue disease affecting internal organs, characterized by a dysregulated immune system and the production of autoantibodies. Patients experience progressive cumulative mortality despite currently available immunosuppressive therapies.Objective. To assess the safety and efficacy of hematopoietic stem cell transplantation (SCT) with the research question: "what is the relative effect on overall mortality in patients with SSc and internal organ involvement treated with SCT compared to t...
Source: Blood - Category: Hematology Authors: Tags: 731. Clinical Autologous Transplantation: Results: Autologous Transplantation: Clonal Hematopoiesis, Microbiota, AML, NHL, and Autoimmune Diseases Source Type: research
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