Does our body clock hold the key to developing new treatments?

Most of us will have felt the temporary effects of a disrupted body clock, whether it’s caused by a long flight, a changing shift pattern or even just a few late nights. Butscientists all over the world now recognise the importance of our biological clocks to lifelong health and well-being.In 2014 Arthritis Research UK invested more than a million pounds into two five-year studies at the University of Manchester investigating how disruption to our daily circadian rhythms is linked to osteoarthritis and inflammatory arthritis. In this edition we’re reporting on how this exciting new research is building our understanding of the role the body clock plays in arthritis and how this knowledge is being used to develop new and more effective treatments.What's the body clock? The body clock is an innate daily timing device, found in most living things. A biological clock ticks in almost every cell in the human body, driving circadian rhythms.Circadian rhythms are physical, mental and behavioural changes that follow a 24-hour cycle. They're controlled primarily by light and darkness in the environment.Circadian rhythms influence how our bodies work, from when we go to sleep and wake up to when hormones are released, from our eating habits and digestion to our body temperature. A fast- or slow-running body clock can disrupt circadian rhythms, having a negative impact on our health and well-being.The body clock, ageing and osteoarthritisResearch led by Qing-Jun Meng, Pr...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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This study had a large sample size and obtained positive findings in both patients’ subjective ratings and in inflammatory marker levels. It demonstrates the benefits of adding Tai Chi to an antidepressant regimen but does not examine the specific effect of Tai Chi on depression.Field et al. (16) investigated the effects of combined Tai Chi/yoga in 92 prenatally depressed pregnant women. They found that women practicing Tai Chi/yoga (20 min per week for 12 weeks) had lower depression, anxiety, and sleep disturbance scores compared to a waitlist control group (Table 1). This study had a large sample size and provided ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
With all our talk of opiate withdrawal syndromes accompanied by nausea, headache, fatigue, and depression, it can be daunting, even terrifying, to people who face the prospect of tossing all wheat and grains into the trash bin, vowing to never let a Danish, donut, or dish of pasta cross your lips again. So it may help to lay out a timeline of what and when various changes can develop in the Wheat Belly wheat- and grain-free lifestyle. You can expect different symptoms and health conditions to recede at different rates, since they are caused by a variety of different mechanisms. For instance, the direct gastrointestinal tox...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle acid reflux detoxification grains IBS Inflammation joint pain opiates withdrawal Source Type: blogs
Most of us will have felt the temporary effects of a disrupted body clock, whether it’s caused by a long flight, a changing shift pattern or even just a few late nights. Butscientists all over the world now recognise the importance of our biological clocks to lifelong health and well-being.In 2014 Arthritis Research UK invested more than a million pounds into two five-year studies at the University of Manchester investigating how disruption to our daily circadian rhythms is linked to osteoarthritis and inflammatory arthritis. In this edition we’re reporting on how this exciting new research is building our unde...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: The quality of the evidence examining physical activity and exercise for chronic pain is low. This is largely due to small sample sizes and potentially underpowered studies. A number of studies had adequately long interventions, but planned follow-up was limited to less than one year in all but six reviews.There were some favourable effects in reduction in pain severity and improved physical function, though these were mostly of small-to-moderate effect, and were not consistent across the reviews. There were variable effects for psychological function and quality of life.The available evidence suggests physica...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
There is a big difference between rheumatoid arthritis and osteoarthritis. Osteoarthritis is the kind from overuse that causes your knee/elbow/hand to hurt when you over use it, or maybe even when you aren't using it. Rheumatoid arthritis is systemic and starts with your little joints - like your feet and hands. The joints become achy and bulge and more.Thisarticle explains better than anything else I have seen on what RA really feels like:Like the fatigue and exhaustion after climbing a mountain or running a marathon.Like the aches and pains after a significant fall or being in a car accident.Like the full body aches and ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: pain rheumatoid arthritis stress Source Type: blogs
ConclusionExtremely small sample sizes, short study duration, heterogeneity of rheumatic conditions and products, and absence of studies of herbal cannabis allow for only limited conclusions for the effects of cannabinoids in rheumatic conditions. Pain relief and effect on sleep may have some potential therapeutic benefit, but with considerable mild to moderate adverse events. There is currently insufficient evidence to recommend cannabinoid treatments for management of rheumatic diseases pending further study.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Rheumatic Diseases Source Type: research
CONCLUSION: To date more than 300,000 patients were assessed, providing the basis for one of the world's largest datasets for chronic pain. Among others the extensive pool of PD-Q data triggered the idea of subgrouping patients on the basis of their individual sensory profiles which might in the future lead to a stratified treatment approach and ultimately to personalised therapy. Started as a healthcare utilisation project in Germany, the PD-Q is nowadays used for clinical and research purposes around the world. PMID: 26907456 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
This study is a population-based cross-sectional study. In this study, 1117 participants aged 40–65 years and living in Shika Town completed a self-administered questionnaire including Short Form-36 (SF-36). The scores of SF-36 among hypertensives were compared with those of normotensives. The independent association of hypertension with each SF-36 subscale was analyzed using a multiple linear regression model adjusted by age, BMI, chronic pain, chronic diseases, sleep, exercise, and occupational status. We analyzed two groups; Group 1 which contained 846 participants completed the questionnaire without coronary...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
Conclusions: There was a unidirectional effect of fatigue on subsequent happiness and a bidirectional relationship between fatigue and frustration within the same-day for adults with RA or OA. These findings inform interventions for the management of mood and fatigue throughout the day and suggest that addressing fatigue could improve mood, and that addressing sources of frustration could improve fatigue among people with arthritis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
Source: Health Psychology - Category: Psychiatry & Psychology Authors: Source Type: research
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