Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2R γcKO.NOD) mice recon...

Source: Malaria Journal - March 14, 2018 Category: Infectious Diseases Authors: Sai Majji, Wathsala Wijayalath, Soumya Shashikumar, Teodor D. Brumeanu and Sofia Casares Tags: Research Source Type: research