Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy Original Articles

Conclusions: This study demonstrates that patient-specific hiPSC cardiomyocytes can recapitulate some phenotypic properties of LGMD2I with DCM and provide a platform for studies on the cardiac events in LGMD.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Arrhythmias, Sudden Cardiac Death, Stem Cells, Translational Studies, Cardiomyopathy Original Articles Source Type: research

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Publication date: Available online 24 May 2020Source: European Journal of RadiologyAuthor(s): Florian A. Huber, Spyridon Gkoumas, Thomas Thüring, Fabio Becce, Roman Guggenberger
Source: European Journal of Radiology - Category: Radiology Source Type: research
Both hair graying and hair loss with age are well researched topics, but there remains considerable uncertainty over which of the possible mechanisms involved are the most relevant, or most useful as targets for therapy. This state of affairs is well illustrated by the feverish interest that attends any possible advance towards reversing male and female pattern baldness. Also the sizable marketplaces devoted to treatments that work poorly, if at all. Today's trial results are interesting, in that I don't recall seeing stem cell factors being used topically before. There is of course a great deal of nonsense and unsc...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 24 May 2020Source: EXPLOREAuthor(s): HongJuan Li, Haoming Huang, Wenjie Long, Junling Zuo, Hongqiang Huang
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
Publication date: Available online 25 May 2020Source: Materials Science and Engineering: CAuthor(s): Alessandra Salvetti, Gaetana Gambino, Leonardo Rossi, Daniele De Pasquale, Carlotta Pucci, Stefania Linsalata, Andrea Degl'Innocenti, Simone Nitti, Mirko Prato, Chiara Ippolito, Gianni Ciofani
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Epigenetics in Primary Sjögren's Syndrome. Adv Exp Med Biol. 2020;1253:285-308 Authors: Bordron A, Devauchelle-Pensec V, Le Dantec C, Capdeville A, Brooks WH, Renaudineau Y Abstract Primary Sjögren's syndrome (SjS) is a chronic and systemic autoimmune epithelitis with predominant female incidence, which is characterized by exocrine gland dysfunction. Incompletely understood, the etiology of SjS is multi-factorial and evidence is growing to consider that epigenetic factors are playing a crucial role in its development. Independent from DNA sequence mutations, epigenetics is described as inheri...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Contributors : Xiangmin Xu ; Peng Huang ; Yongzhong Zhao ; Jianmei ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSC) involved in the generation of red cells is critical for understanding dynamic developmental changes that accompany human erythropoiesis. Using Single-cell RNA sequencing (scRNA-seq) of primary human terminal erythroid cells (CD34 −CD235a+) isolated directly from adult bone marrow (BM) and umbilical cord blood (UCB), we documented the transcriptome of terminally differenti...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : G L Maier ; Johannes Bues ; Marjan Bio Ĩanin ; Felix Meyenhofer ; Clarisse Brunet Avalos ; Jae Y Kwon ; Bart Deplancke ; Simon G SprecherSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe ability to evaluate food palatability is innate in all animals from insects to mammals, ensuring their survival. The external taste organ at the periphery in Drosophila larvae is composed of only few sensory neurons but displays discrimination between a wide range of chemicals as well as a high level of complexity in receptor expression and cell response profile. Taking ad...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
Contributors : Jorke H Kamstra ; Thomas W Fraser ; Vidar Berg ; Erik Ropstad ; Maria ChristouSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPersistent organic pollutants (POPs) are widespread in the environment and bioaccumulate in organisms. Previously we observed hyperactivity of zebrafish larvae exposed to a mixture of POPs based on average blood levels from the Scandinavian population and identified perfluorooctanesulfonic acid (PFOS) as the driving agent for the behavioral changes. We exposed zebrafish larvae from 6 to 96 h post fertilization to the same mixture of POPs in two co...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Contributors : Pedro Rifes ; Marc Isaksson ; Gaurav S Rathore ; Patrick A kirk ; Oliver K M øller ; Guido Barzaghi ; Julie Lee ; Kristoffer L Egerod ; Dylan M Rausch ; Malin Parmar ; Tune H Pers ; Thomas Laurell ; Agnete KirkebySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStudies in animal models have been fundamental for understanding brain development but only a fraction of these findings have been validated in a human context. Here, we tissue-engineered a model (MiSTR) of human neural tube regionalization based on human embryonic stem cells (hESCs) and microfluidic cell c...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Nada Zaidan ; Evangelia Diamanti ; Katrin OttersbachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this study was to examine the whole transcriptome of pools of 20 cells of Gata3-expressing AGM subpopulations (haematopoietic [HC], mesenchymal [MC], sympathetic nervous system [SNS], and endothelial [EC]) and compare them to their non-Gata3 expressing counterparts
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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