Abnormal Heavy/Light Chain Ratio and Matched Pair Suppression Increase Residual Disease Detection Sensitivity in Patients With Multiple Myeloma With Deep Responses

Conclusion Abnormal HLC ratios and HLC-matched pair suppression can increase the sensitivity for detecting residual disease in patients with multiple myeloma with deep responses. Micro-Abstract Heavy/light chain (HLC) assay can quantify involved as well as uninvolved immunoglobulin pairs. We compared the sensitivity between HLC assay and other examinations in patients with multiple myeloma. The lower the monoclonal protein levels, the more the possibility that the patients had normal HLC ratios and no matched pair suppression. Abnormal HLC ratios and HLC-matched pair suppression can increase the sensitivity.

Source: Clinical Lymphoma Myeloma and Leukemia - March 15, 2018 Category: Cancer & Oncology Source Type: research