Corrigendum to “Phenotype continuum between autism and schizophrenia: Evidence from the Movie for the Assessment of the social cognition (MASC)” Schizophr. Res. 185 (2017) 161–166

The authors regret.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Corrigendum Source Type: research

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I have written before about atypical presentations of obsessive-compulsive disorder in children, where I discuss how the symptoms of OCD are sometimes confused with autism, schizophrenia, and even Bipolar Disorder. I’ve also written about how diagnosing these various conditions can be difficult, as symptoms of each one often overlap. Sometimes it is easy to forget that we are talking about a whole person’s state of being, not just a specific diagnosis. No doubt people have manifested symptoms of these various illnesses long before the disorders were differentiated by names. Still, a proper diagnosis is importa...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Autism Children and Teens OCD Research anxiety Autism Spectrum Compulsions Obsessions Source Type: blogs
(MedPage Today) -- Similar association not observed for bipolar disorder or psychosis, including schizophrenia
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
acute;vi S Abstract Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and autism are associated with altered neuronal chloride (Cl-) homeostasis. A current view is that the accumulation of intracellular Cl- in neurons as a result of KCC2 down-regulation and/or NKCC1 up-regulation may weaken inhibitory GABA signaling and ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
Publication date: Available online 2 March 2019Source: NeuroImageAuthor(s): Kamalaker Dadi, Mehdi Rahim, Alexandre Abraham, Darya Chyzhyk, Michael Milham, Bertrand Thirion, Gaël Varoquaux, for the Alzheimer's Disease Neuroimaging InitiativeAbstractFunctional connectomes reveal biomarkers of individual psychological or clinical traits. However, there is great variability in the analytic pipelines typically used to derive them from rest-fMRI cohorts. Here, we consider a specific type of studies, using predictive models on the edge weights of functional connectomes, for which we highlight the best modeling choices. We sy...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: 5 March 2019Source: Cell Reports, Volume 26, Issue 10Author(s): Sara Marie Katrancha, Juliana E. Shaw, Amy Y. Zhao, Samuel A. Myers, Alexandra R. Cocco, Amanda T. Jeng, Minsheng Zhu, Christopher Pittenger, Charles A. Greer, Steven A. Carr, Xiao Xiao, Anthony J. KoleskeSummaryHeterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hippocampus of mice. Trio haploi...
Source: Cell Reports - Category: Cytology Source Type: research
Abstract Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS) that initiates a rapid signal transmission in the synapse before its re-uptake into the surrounding glia, specifically astrocytes. The astrocytic glutamate transporters, glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and their human homologs excitatory amino acid transporter 1 (EAAT1) and 2 (EAAT2), respectively, are the major transporters that take up synaptic glutamate to maintain its optimal extracellular levels, thus preventing its accumulation in the synaptic cleft and the ensuing exc...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
Mutations of the TRIO gene cause some of the same structural and behavioral abnormalities found with autism, schizophrenia, bipolar disorder, and epilepsy.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
Authors: Kaliora SC, Zervas IM, Papadimitriou GN Abstract Electroconvulsive therapy (ECT) is the oldest among the early biological treatments introduced in psychiatry, and the only one still in use. In this paper we attempt a brief presentation of ECT usage over the last 80 years, since it was originally introduced. It is a safe, well-tolerated, and highly effective treatment option for major psychiatric disorders, such as mood disorders and schizophrenia, especially when there is an acute exacerbation of psychotic symptoms or if catatonic symptoms are prominent. ECT has also been used successfully for the treatmen...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Abstract The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with several alternative partners; the structure of the protein assembly can be regulated in an activity-dependent manner. A major scaffolding molecule in the PSD is Shank, a family of three main isoforms with highly similar domain structure. Proteins of the Shank family are targets of mutations in neurological disorders, such as autism and schizophrenia. All the predicted folded domains of Sha...
Source: Current Opinion in Structural Biology - Category: Biology Authors: Tags: Curr Opin Struct Biol Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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