A subset of functional adaptation mutations alter propensity for α-helical conformation in the intrinsically disordered glucocorticoid receptor tau1core activation domain

Conclusions Changes in PreSMo stability account for the effects of a subset of change-of-function mutants affecting the GR tau1core IDR. General significance Long IDRs occur in about 50% of human proteins. They are poorly characterized despite much recent attention. Our results suggest the importance of a subtle balance between PreSMo stability and IDR activity, which may provide a novel target for future pharmaceutical intervention.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 15, 2018 Category: Biochemistry Source Type: research