Genetic Variation and Chronic Kidney Disease Progression

African Americans with chronic kidney disease and two copies of the APOL1 gene are more likely to progress to kidney failure, suggesting need for new screening.
Source: NIDDK News - Category: Endocrinology Source Type: news

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Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: YF acute severe cases show a generalised involvement of different organs (liver, spleen, heart, kidneys, intestines and pancreas), and different parameters were related to outcome. Factor V and lipase are independent variables associated with death, reinforcing the importance of hemorrhagic events due to fulminant liver failure and pointing to pancreatitis as a relevant event in the outcome of the disease. PMID: 31116245 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Authors: Herrera-Añazco P, Atamari-Anahui N, Flores-Benites V Abstract We conducted a descriptive and ecological study that evaluated the relationship between the prevalence trend of patients with chronic kidney disease (CKD), the number of nephrologists, and the number of hemodialysis services of the Ministry of Health (MINSA). The study was based on a secondary analysis of the care provided by MINSA, the Observatory of Human Resources in Health, and the hemodialysis services registered as Health Service Providers of the Intangible Health Solidarity Fund (FISSAL, in Spanish). The adjusted prevalence of CKD ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
In this study, the relationship between HDL-C variability and the risk for progression to end-stage renal disease (ESRD) was investigated.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Publication date: Available online 6 May 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Shanika Nanayakkara, Xiaoyan ZhouArticle Title and Bibliographic InformationThe directional and nondirectional associations of periodontitis with chronic kidney disease: A systematic review and meta-analysis of observational studies. Zhao D, Khawaja AT, Jin L, Li K–Y, Tonetti M, Pelekos G. J Perio Res 2018; 53(5):682-704.Source of FundingThe authors' own institution, University of Hong Kong.Type of Study/DesignSystematic review with meta-analysis of data.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
The objective of this review is to know what is available in the literature on the dose of heat disinfection that should be used in hemodialysis and to present our experience with this method at a set dose of 12.000 A0. PMID: 31109712 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
AbstractPurpose of ReviewDespite enhanced screening and therapeutic management, hypertension remains the most prevalent chronic disease in the United States and the leading cause of heart disease, chronic kidney disease, and stroke in both men and women. It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes and end organ damage. Despite known discrepancies in the risk of hypertension development between men and women, preclinical models of immune-mediated hypertension were historically developed solely in male animals, leading ...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
AbstractStrongyloides stercoralis (S. stercoralis), a human intestinal nematode, can lead to hyper/disseminated (HD) infection in patients treated with corticosteroids. Here, we report a case of strongyloidiasis in a 58-year-old female with a history of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). The patient presented with abdominal pain and gastrointestinal (GI) bleeding. Stool was negative for parasitic agents in the first direct smear examination, and the patient with the probable diagnosis ofHelicobacter pylori (H. pylori) infection or Crohn ’s disease received antibiotics and corticosteroids. ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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