Scientists Discover New Drugs To Treat Hot Flashes

BOSTON (CBS) — Scientists at Imperial College London have developed a new class of experimental drugs to treat menopausal hot flashes. In a clinical trial involving 37 women, the compound called MLE4901 reduced the number of hot flashes by almost three-quarters and significantly reduced the severity. The drug blocks a chemical in the brain called neurokinin B and in the study the drug also improved sleep and concentration during the 4-week study period. MLE4901 can affect liver function but two similar drugs which don’t have this side effect are being studied in larger patient trials including one in the U.S. that was launched last year. There aren’t a lot of effective treatments for hot flashes, other than hormone replacement therapy, which can increase the risk of breast cancer and blood clots, so new drugs are sorely needed. menopause
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Healthwatch Local News Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall Menopause Women's Health Source Type: news

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Source: Contemporary Neurosurgery - Category: Neurosurgery Tags: ARTICLE Source Type: research
Authors: Kalkbrenner C, Brucher R, Kesztyüs T, Eichenlaub M, Rottbauer W, Scharnbeck D Abstract The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. A minimalistic type-4 monitoring system which utilized tracheal body sound and actigraphy to accurately diagnose the obstructive sleep apnea syndrome was previously develo...
Source: GMS German Medical Science - Category: General Medicine Tags: Ger Med Sci Source Type: research
Publication date: Available online 19 April 2019Source: Biosensors and BioelectronicsAuthor(s): Bo Dong, Kaixuan Nie, Huanhuan Shi, Lemeng Chao, Mingyang Ma, Fengxiao Gao, Bo Liang, Wei Chen, Mengqiu Long, Zhengchun LiuAbstractPeptide nucleic acids array technology is a method of greatly increasing the throughput of laboratory processes to efficiently perform large-scale genetic tests. Diethylene glycol-containing chiral γPNA (miniPEG-γPNA) is considered to be the best PNA derivative and one of the best candidates for gene detection, because it can hybridize DNA with greater affinity and sequence selectivity th...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
This study aimed to examine the prevalence of REM-related OSA in narcolepsy patients. Methods From January 2013 to April 2018, 141 adult patients were diagnosed with narcolepsy using nocturnal polysomnography and the multiple sleep latency test. The prevalence of REM-related OSA in narcolepsy patients was retrospectively reviewed. Three criteria were used to determine REM-related OSA: Definition #1, an overall apnea-hypopnea index (AHI) ≥5 and AHI during REM (AHIREM)/AHI during non-rapid eye movement (NREM) (AHINREM) ≥2; Definition #2, an overall AHI ≥5 and AHIREM/AHINREM≥2 and AHINREM
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Ishimaru N, Kanzawa Y, Seto H, Kinami S Abstract We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. The rapid plasma reagin ratio was 1:3. She was diagnosed with syphilitic cervicitis and treated with amoxicillin for four weeks. Initial cervical cytology showed cells with mild nuclear enlargement, which was thought to be metaplasia ass...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research
Publication date: October 2016 Source:Brain, Behavior, and Immunity, Volume 57, Supplement Author(s): C. Xiao, A. Miller, J. Felger, D. Mister, T. Liu, M. Torres The purpose of this study was to examine predictors of fatigue in breast cancer survivors one-year post-radiotherapy. This cross-sectional, observational study enrolled 111 patients treated with breast conserving surgery followed by whole breast radiotherapy. Half of the patients received chemotherapy. The primary outcome variable was fatigue, measured by the Multidimensional Fatigue Inventory-20. Predictors included inflammation, age, race, marital status, smoki...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews ...
Source: EPMA Journal - Category: Global & Universal Source Type: research
Purpose of review: Provide evidence-based recent data on oral micronized progesterone (OMP) and progestins in menopausal hormonal therapy (MHT). Recent findings: Medroxyprogesterone acetate (MPA) increases breast cancer acting through the glucocorticoid receptor; progestins in MHT increase thrombosis more than oral estrogens; MPA, but not OMP or other progestins, increase monocyte cell endothelium adhesion; MPA and estradiol (E2)/MPA have negative brain effects, whereas E2/progesterone (P4) has neuroregenerative brain effects. The ‘window of opportunity’ cardiovascular disease hypothesis is not supported by a r...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: Reproductive Endocrinology Source Type: research
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