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Many patients show signs of chronic kidney disease before diabetes diagnosis

(Veterans Affairs Research Communications) Many patients who will later be diagnosed with diabetes show signs of chronic kidney disease even before their diabetes diagnosis, according to a study by Veterans Affairs researchers and colleagues in Tennessee. The researchers looked at data on more than 36,000 veterans who were diagnosed with diabetes between 2003 and 2013.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Ha KH, Kim B, Shin HS, Lee J, Choi H, Kim HC, Kim DJ Abstract BACKGROUND AND OBJECTIVES: To compare cardiovascular disease (CVD) risk associated with 5 different dipeptidyl peptidase-4 inhibitors (DPP-4is) in people with type 2 diabetes. METHODS: We identified 534,327 people who were newly prescribed sitagliptin (n=167,157), vildagliptin (n=67,412), saxagliptin (n=29,479), linagliptin (n=220,672), or gemigliptin (n=49,607) between January 2013 and June 2015 using the claims database of the Korean National Health Insurance System. A Cox proportional hazards model was used to estimate hazard ratios (HRs)...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Authors: Tong L, Adler S Abstract Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications. Understanding the treatment considerations specific to each class of T2D...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
We thank Dr. Labriola and Dr. Jadoul for their comments.1 We fully agree with the relevance of falls as a major risk factor of fracture in such patients.2 Falls were mentioned and included in Figure  12 as an important determinant of fractures. However, this issue was not extensively discussed because of few relevant data available in chronic kidney disease (CKD) patients. CKD patients, including those treated by dialysis, may have a high propensity for falls. Several factors are probably invo lved, including accelerated aging with deleterious consequences such as impaired cognitive function, neurological disorders, v...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Boehringer Ingelheim and Eli Lilly and Company (NYSE:LLY) have announced an academic collaboration with the University of Oxford. EMPA-KIDNEY will investigate the effects of empagliflozin on the progression of kidney disease and the occurrence of cardiovascular death, in people with established chronic kidney disease with and without diabetes.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news
Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function.
Source: Archives of Medical Research - Category: Research Authors: Tags: Original Article Source Type: research
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease, Published online: 13 April 2018; doi:10.1038/s41581-018-0001-yPatients who present with chronic kidney disease and diabetes mellitus can have true diabetic kidney disease (DKD), nondiabetic kidney disease (NDKD), or a combination of both DKD and NDKD. Here, Anders and colleagues discuss the mechanisms underlying these entities and how greater appreciation of distinctions between these entities might facilitate the development of new treatments.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Publication date: Available online 13 April 2018 Source:American Journal of Kidney Diseases Author(s): Nisa Desai, Claudia M. Lora, James P. Lash, Ana C. Ricardo Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among His...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Conclusions: The results showed that chronic conditions and multiple chronic conditions are prevalent in older adults across Florida and the United States. Even though slight differences were observed, the similar estimates of prevalence of chronic conditions and multiple chronic conditions across OneFlorida and HCUP NIS suggested that clinical research data networks such as OneFlorida, built from heterogeneous data sources, can provide rich data resources for conducting large-scale secondary data analyses.
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Publication date: Available online 11 April 2018 Source:Pregnancy Hypertension Author(s): Kirsty G. Pringle, Celine Corbisier de Meaultsart, Shane D. Sykes, Loretta J. Weatherall, Lyniece Keogh, Don C. Clausen, Gus A. Dekker, Roger Smith, Claire T. Roberts, Kym M. Rae, Eugenie R. Lumbers The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal diseas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
More News: Chronic Kidney Disease | Diabetes | Endocrinology | Study | Urology & Nephrology