Successful Pregnancy Outcomes Following Liver Transplantation Is Predicted By Renal Function

ABSTRACT Background: Liver transplantation (LT) is a successful treatment for both acute liver failure and end‐stage liver disease. The number of women of reproductive age undergoing LT is increasing. Pregnancy outcomes are favourable but there is still a lack of prognostic markers. We aimed to identify factors predictive of adverse pregnancy outcomes in LT recipients. Methods: An analysis of all pregnancies occurring in LT recipients from 1989‐2016 at King's College Hospital was performed. Clinical data of 162 conceptions in 93 women was reviewed. Descriptive and regression analyses were done to examine associations between laboratory markers and hepatological scores with pregnancy outcomes of live birth and preterm birth. Results: Median age at LT was 23 years (1‐41), with a median age at conception of 30 years (18‐47). The live birth rate was 75% (n=121). Of live births, 35% (n=39/110 available) were delivered preterm. Pre‐conception creatinine levels were higher in patients who had a preterm birth (85 μmol/L vs 74 μmol/L, p=0.008), with a pre‐conception estimated glomerular filtration rate (eGFR)
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research

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ConclusionRRA must be initiated within 58 days after surgery in patients with high-risk DTCs. Under this approach, risk of SIR and associated mortality risk may be reduced. RRA timing for women in reproductive ages with low/intermediate risk groups may be planned according to their pregnancy/breastfeeding intent. For other low/intermediate risk groups, they can safely proceed according to the capacity of the medical facility and related logistical considerations.ResumenIntroducciónEs difícil adoptar un enfoque científico basado en la evidencia con respecto al intervalo de aplicación de la ablaci...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
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Authors: Mouton CP, Haas A, Karmarkar A, Kuo YF, Ottenbacher K Abstract Elder abuse and mistreatment (EM) continues to be a growing problem as the US population ages. Despite the growth, detection of EM continues to lag. However, Medicare claims data and the electronic health record might provide an opportunity to encourage better detection. We evaluated Medicare claims data from 2012-2014 for beneficiaries who had a diagnostic code for EM discharged from any types of facility. We extracted records for 10,181 individuals examining demographic characteristics, residential characteristics, residential location, type ...
Source: Journal of Elder Abuse and Neglect - Category: Geriatrics Tags: J Elder Abuse Negl Source Type: research
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Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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Source: Physiology and Behavior - Category: Physiology Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
United Therapeutics Corp. can add another regulatory thumbs-up to its growing collection. The Silver Spring biotech has earned Food and Drug Administration approval for another use of Orenitram, a pulmonary arterial hypertension drugs first approved in 2013 to improve patients’ ability to exercise. The agency’s new stamp means the drug’s label can now reflect that it delays the d isease’s progression when used with another type of PAH therapy, United Therapeutics (NASDAQ: UTHR) said Monday. In…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
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Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
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Source: Reproductive Toxicology - Category: Toxicology Source Type: research
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