What Is the Effect of High-dose Radiation on Bone in Patients With Sacral Chordoma? A CT Study.

CONCLUSIONS: Trabecular bone density decreased after high-dose radiation therapy in a small group of patients with sacral chordoma. High-dose radiation is increasingly gaining acceptance for treating sacral malignancies; further long-term prospective studies using calibrated CT scanners and preferably bone biopsies are needed.
LEVEL OF EVIDENCE: Level IV, therapeutic study.
PMID: 29529635 [PubMed - in process]

Source: Clinical Orthopaedics and Related Research - March 1, 2018 Category: Orthopaedics Authors: van Wulfften Palthe O, Jee KW, Bramer JAM, Hornicek FJ, Chen YE, Schwab JH Tags: Clin Orthop Relat Res Source Type: research