CORR Insights ®: What Are the Complications of Allograft Reconstructions for Sarcoma Resection in Children Younger Than 10 Years at Long-term Followup?

CORR Insights®: What Are the Complications of Allograft Reconstructions for Sarcoma Resection in Children Younger Than 10 Years at Long-term Followup? Clin Orthop Relat Res. 2018 Mar;476(3):556-558 Authors: Nicholas RW PMID: 29529640 [PubMed - in process]
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research

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limb salvage is a priority in pediatric patients with bone sarcomas. The vascularized fibula flap is a versatile option, combined or not with a bone allograft. The authors evaluated the functional long-term outcomes, complications and survival of using this technique in pediatric patients.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
ConclusionFunctional reconstructions in extremity STS are rarely described, but generally result in good functionality in spite of multimodal treatment. Early participation of reconstructive surgeons may help achieve ideal functional and oncological outcomes.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusion: Biological restoration of elbow anatomy using osteoarticular irradiated graft for proximal ulna reconstruction offers great joint stability and functional outcomes. Although the potential risks of infection and graft failure need to be considered, reconstruction with the size-matched radiated autograft eliminates donor site morbidity, offers a low-cost alternative to endoprosthesis, and provides outcomes superior to any other methods of reconstruction as analyzed from the literature. PMID: 31110466 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
The objectives of this case-control study were to determine whether PSI-guided resection: 1) was associated with a lower local recurrence rate, 2) allowed a shorter operative time, 3) was associated with better-quality allograft reconstruction.HypothesisPSI-guided resection decreases the local recurrence rate by improving the resection margins in patients with primary pelvic bone sarcomas.Patients and methodsPSI-guided resection was performed in 9 consecutive patients (cases) with primary pelvic sarcomas (chondrosarcoma, n = 3; Ewing's sarcoma, n = 3; osteosarcoma, n = 1; fibrosarcoma, n ...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Conclusions Lymphatic vessels, like blood vessels, are a highly interactive surface for cells of the immune system, and through the use of chemokines and their receptors can coordinate key interactions. These pathways can control the entry and function of particular immune subsets in a number of pathological conditions. Nonetheless LECs have distinct patterns of chemokine secretion and expression of chemokine receptors that distinguish them from the blood vessel system and mediate distinct roles and responses. The abundance and diversity of the chemokine family point to the likelihood that a plethora of novel chemokine fu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We present the case of an adolescent male patient treated in our Department for a tumoral mass located in the middle third of the forearm. Magnetic resonance imaging (MRI) and angiography-computed tomography (angio-CT) showed a large mass located in the muscles of the anterior compartment of the forearm. Surgical treatment consisted of tumor ablation including segmental resection of the radial and ulnar arteries and of the median nerve, followed by saphenous autograft vascular bypass. The treatment plan was based on tumor type, histological grading (high), age, tumor size greater than 5 cm, unfavorable location, postoperat...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
ConclusionsWe have demonstrated similar failure rates for both reconstructions. In both techniques, mechanical failure was the most common complication with a low rate of limb amputation and good functional results.Level of evidenceLevel III, therapeutic study.
Source: Musculoskeletal Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 28 February 2019Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Samuele Iesari, Milton Eduardo Inostroza Núñez, Juan Manuel Rico Juri, Olga Ciccarelli, Eliano Bonaccorsi-Riani, Laurent Coubeau, Pierre-François Laterre, Pierre Goffette, Chantal De Reyck, Benoît Lengelé, Pierre Gianello, Jan LerutAbstractBackground: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor live...
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing ’s sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the pres ence of E. ramosum, an anaerobic firmicute with a low Gram-positive affinity staining and low GC content, that was further characterized by whole genome sequencing (WGS).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
Segmental resection of a tumor in the long bones can be treated with biological reconstruction including allograft or inactivated autograft. Allografts and inactivated autograft have been most successful in intercalary and intraarticular reconstructions, with the advantages over prosthetic reconstruction in that it restores bone stock, avoids the prosthetic complication and provides possibly a lifelong biologic reconstruction. The structural allograft and inactivated autograft are appropriate alternatives in limb reconstruction after massive resection of involved tissues in malignant bone tumors and both can acquire satisf...
Source: Injury - Category: Orthopaedics Authors: Source Type: research
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