[Comment] Hypercholinergic activity in LRRK2 Parkinson's disease

Mutations of the LRRK2 gene are a common cause of autosomal-dominant Parkinson's disease. The clinical features of manifest LRRK2 Parkinson's disease are generally indistinguishable from those of sporadic Parkinson's disease, although some features might be less prominent, including diminished hyposmia and less cognitive decline.1 Study of premanifest LRRK2 Parkinson's disease has the potential to identify early and important events in Parkinson's disease pathophysiology and pathogenesis. Cholinergic system changes are implicated in several non-motor features of idiopathic Parkinson's disease.

Source: Lancet Neurology - February 15, 2018 Category: Neurology Authors: Nicolaas I Bohnen, Roger L Albin Tags: Comment Source Type: research