Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses

Live vaccines typically elicit augmented humoral responses, affording superior protection. Barbet et  al. report that innate detection of bacterial RNA, a signature of microbial viability, directs a heightened Tfh cell response. This response is extrinsic to B cells and dendritic cells and involves CX3CR1+CCR2– monocyte instruction of Tfh differentiation via TRIF-dependent IFN-β licensing of ba cterial RNA-driven inflammasome activation.

Source: Immunity - March 13, 2018 Category: Allergy & Immunology Authors: Gaetan Barbet, Leif E. Sander, Matthew Geswell, Irina Leonardi, Andrea Cerutti, Iliyan Iliev, J. Magarian Blander Tags: Article Source Type: research