In Vivo Short-Term Topical Application of BAY 11-7082 Prevents the Acidic Bile-Induced mRNA and miRNA Oncogenic Phenotypes in Exposed Murine Hypopharyngeal Mucosa.
CONCLUSION: There is novel evidence that acidic bile-induced NF-κB-related oncogenic mRNA and miRNA phenotypes are generated after short-term 7-day mucosal exposure and that topical mucosal application of BAY 11-7082 can prevent the acidic bile-induced molecular alterations associated with unregulated cell growth and proliferation of hypopharyngeal cells.
PMID: 29529473 [PubMed - as supplied by publisher]
Source: Neoplasia - Category: Cancer & Oncology Authors: Sasaki CT, Doukas SG, Vageli DP Tags: Neoplasia Source Type: research
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