In Vivo Short-Term Topical Application of BAY 11-7082 Prevents the Acidic Bile-Induced mRNA and miRNA Oncogenic Phenotypes in Exposed Murine Hypopharyngeal Mucosa.

CONCLUSION: There is novel evidence that acidic bile-induced NF-κB-related oncogenic mRNA and miRNA phenotypes are generated after short-term 7-day mucosal exposure and that topical mucosal application of BAY 11-7082 can prevent the acidic bile-induced molecular alterations associated with unregulated cell growth and proliferation of hypopharyngeal cells. PMID: 29529473 [PubMed - as supplied by publisher]
Source: Neoplasia - Category: Cancer & Oncology Authors: Tags: Neoplasia Source Type: research

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Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Marc Arbyn, Elisabete Weiderpass, Laia Bruni, Silvia de Sanjosé, Mona Saraiya, Jacques Ferlay, Freddie BraySummaryBackgroundThe knowledge that persistent human papillomavirus (HPV) infection is the main cause of cervical cancer has resulted in the development of prophylactic vaccines to prevent HPV infection and HPV assays that detect nucleic acids of the virus. WHO has launched a Global Initiative to scale up preventive, screening, and treatment interventions to eliminate cervical cancer as a public health problem during th...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Afsan Bhadelia
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
A new "virtual biopsy" using ultrasound guidance allows doctors to definitively...Read more on AuntMinnie.comRelated Reading: USPSTF again dismisses pancreatic cancer screening New class of radiotracers targets many cancer types Can radiomics detect pancreatic ductal adenocarcinoma? Optical imaging finds small tumors
Source: Headlines - Category: Radiology Source Type: news
CHICAGO - What are the distinct benefits of 3D printing and augmented reality...Read more on AuntMinnie.comRelated Reading: 3D printing helps unravel rare cardiac anomalies 4 core applications of cardiovascular 3D printing AR, 3D printing enhance planning for complex heart surgery AR, 3D printing aid presurgical planning for kidney cancer 3D printing gives pediatric heart surgery a boost
Source: Headlines - Category: Radiology Source Type: news
A shorter round of higher-dose radiation to part of the breast demonstrates...Read more on AuntMinnie.comRelated Reading: ASTRO: Whole, partial breast RT yield similar cosmetic results Stereotactic radiation extends long-term survival ASTRO: Breast radiation 'less scary' than expected ASTRO releases updated APBI guide
Source: Headlines - Category: Radiology Source Type: news
Researchers from Washington University in St. Louis have developed a new imaging...Read more on AuntMinnie.comRelated Reading: Optical imaging technique better predicts heart attacks Is an accurate two-minute biopsy viable? Skin imaging firm lauds CPT recommendation for OCT Australian group develops new optical breast imaging technique
Source: Headlines - Category: Radiology Source Type: news
Contributor : Janet L StanfordSeries Type : Expression profiling by arrayOrganism : Homo sapiensPrognostic biomarkers are useful to screen patients with clinically localized prostate cancer (PCa) who are at high risk of metastatic progression. The tumor transcriptome can be used to evaluate the aggressiveness of PCa and predict adverse patient outcomes. Genomewide gene expression levels were measured in primary tumor samples of 503 patients in a population ‐based cohort.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
This study demonstrated that a homogeneous polysaccharide (HPS) extracted from Hawthorn exerted anti-cancer effects on colon cancer cells. Human colon cancer cell line HCT116 were treated with 125–1000 µg/mL HPS for 12 h and subsequent analysis was performed on proliferation and signaling pathways. HPS significantly inhibited proliferation of HCT116 cells when analyzed using WST-1 assay and immunofluorescence staining of Ki-67. Flow cytometric studies revealed that HPS could arrest the cell cycle in the S and G2/M phases and increase the rate of apoptosis. HPS downregulated the expression of Cyclin A1...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Abstract INTRODUCTION: The aim of this study was to evaluate the current indications for and clinical factors influencing the use of transnasal esophagoscopy (TNE). METHODS: An online survey was sent to American Broncho-Esophagological Association members, including questions on demographics, indications, and factors influencing the use of TNE. RESULTS: Sixty of 251 members (24%) completed the survey. Ninety-three percent of respondents reported academic practices, while 98% practice in medium to large urban settings. Thirty-five (58%) completed laryngology fellowships. Mean monthly TNE procedure count was 7.15 (range,
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
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