Genetic Testing Underused in Breast Cancer Cases

The study included just over 1,700 women with early stage breast cancer who could benefit from genetic testing.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Juliet, who blogs about her recovery from cancer, explains why she didn’t want breast reconstruction after her mastectomy.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Abstract There are rare benign diseases that can mimic malignant breast neoplasms in the clinical exam and in mammography. We evaluated the contribution of an accessible procedure to most clinicians, the fine-needle aspiration cytology, to identify a rare mimicker of malignant breast neoplasms. A type 2 diabetic 85-year-old female presented with a 6-month history of a left breast lump. The physical exam and mammography were compatible with breast cancer. Nevertheless, after fine-needle aspiration cytology, the diagnosis was plasma cellmastitis. Once this rare diagnosis was established, the tumor was extirpated, and the fin...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
OBJECTIVES: Cancer in young adults represents a great challenge, both biologically and socially, and understanding the unique characteristics of neoplasms in this age group is important to improving care. We aimed to evaluate the most common carcinomas and their characteristics, such as histological type and clinical stage, in young adults in the largest cancer hospital in Latin America. METHODS: The hospital registry was consulted for the period between 2008 and 2014. Young adults were defined as individuals aged 18 to 39 years, and older adults were defined as individuals aged 40 years and older. Differences between age ...
Source: Clinics - Category: General Medicine Source Type: research
In this study, we fused Tα1 to Fc domain of human IgG1 for generation of a novel long-acting fusion protein, termed Tα1-Fc. Tα1-Fc was expressed, purified, and identified. The results showed that Tα1-Fc was more potent than Tα1 in inhibiting the growth of 4T1 and MCF-7 breast cancer cells in vivo. Furthermore, in the 4T1 tumor model the mice treated with Tα1-Fc exhibited higher level of CD4 and CD8 cells compared with that of the mice Tα1 treated. The interferon-γ and interleukin-2 level in the Tα1-Fc-treated mice was higher than that in the Tα1-treated mice. T&al...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Technology can be used to identify the molecular markers of breast cancer tumors
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Pathology, Journal, Source Type: news
Authors: Li L, Liu S, Liu L, Ma Z, Feng M, Ye C, Zhou W, Wang Y, Liu L, Wang F, Yu L, Zhou F, Xiang Y, Huang S, Fu Q, Zhang Q, Gao D, Yu Z Abstract The expression of insulin-like growth factor-1 receptor (IGF-1R), which is involved in the genesis and progression of breast cancer, is thought to be associated with the overall survival (OS) of patients. However, the predictive and prognostic significance of the IGF-1R expression in breast cancer remains controversial. The present study aimed to identify the factors associated with the levels of phosphorylated (p)-IGF-1R in breast cancer, their impact on the outcomes o...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: October 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 10Author(s): G. Sena
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This study aims to investigate the correlations between the expression of human epidermal growth factor receptor 2 (C-erB-2), CD34, and estrogen receptor (ER) in breast cancer (BC) patients, and the signs of conventional ultrasonography and ultrasound elastography. PATIENTS AND METHODS: Clinical data of 88 patients who were pathologically diagnosed as breast cancer were retrospectively analyzed. HI VISION Avius color ultrasound device was used to perform ultrasound and related ultrasound parameters were analyzed. Expressions of C-erB-2, CD34, and ER were detected by immunohistochemistry. RESULTS: There was a correl...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
FRIDAY, Sept. 21, 2018 -- Molecular markers of breast cancer tumors can be identified by focusing on parameters of a cell's nucleus, and aided by machine learning, according to a study published online Sept. 4 in npj Breast Cancer. Rishi R. Rawat,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 20 September 2018Source: Journal of Biomedical InformaticsAuthor(s): Alex Graudenzi, Davide Maspero, Marzia Di Filippo, Marco Gnugnolo, Claudio Isella, Giancarlo Mauri, Enzo Medico, Marco Antoniotti, Chiara DamaniAbstractEffective stratification of cancer patients on the basis of their molecular make-up is a key open challenge. Given the altered and heterogenous nature of cancer metabolism, we here propose to use the overall expression of central carbon metabolism as biomarker to characterize groups of patients with important characteristics, such as response to ad-hoc therapeutic strateg...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
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