J & J, Macleods in talks for licence deal of tuberculosis drug

The talks, which are in early stage, will allow Macleods to manufacture generic version of the drug, a move if goes through will improve access to this new TB drug.
Source: The Economic Times - Category: Consumer Health News Source Type: news

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ConclusionsWe observed a significant relationship between mining tenure and emphysema severity among South African miners in PATHAUT between 1975 and 2014. This relationship was evident in multi-variable analyses adjusted for smoking among white miners. Hazards from long term exposure to inhaled mineral dust leading to lung damage (silicosis, fibrosis, COPD) is evident and warrants further improvement of working conditions and prevention measures in South African mines especially for black workers. Further research is needed to determine if there is an effect of TB and HIV co-infection on the development of emphysema.
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
Authors: Milford C, Greener LR, Beksinska M, Greener R, Mabude Z, Smit J Abstract In South Africa, a lack of integration between sexual and reproductive health (SRH) and HIV services has led to lost opportunities in the treatment cascade. In a context of high HIV, tuberculosis (TB) and unplanned pregnancies, a model for integrating SRH and HIV services was implemented in a hospital and six feeder clinics in KwaZulu-Natal, South Africa. Changes in healthcare provider knowledge, attitudes and understandings were explored following model implementation. Baseline data were collected via focus group discussions (FGDs) a...
Source: African Journal of AIDS Research - Category: African Health Tags: Afr J AIDS Res Source Type: research
CONCLUSION: Despite contacts being well documented, child contacts were poorly identified. The fall-out of children at each step from identification to IPT completion was unacceptably high. Contacts of male patients and retreatment index patients were at greater risk of poor management. Recommendations to improve IPT delivery at national and local level include a review of the national IPT guidelines, considering the relative success of shorter courses of TB prophylaxis, the use of standardised IPT stationery, staff training and the involvement of community health workers in contact management. PMID: 30004366 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Allwood BW, Maarman GJ, Kyriakakis CG, Doubell AF PMID: 30004336 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
ConclusionThis report describes cross-transmission ofMycobacterium tuberculosis from non-citizens MOHA to Israeli citizens who were residents of a nursing home, which may be the first sign for an epidemiological shift. Although cross-ethnical transmission is still rare in Israel, medical settings should employ efficient infection control measures to protect both patients and staff fromMycobacterium tuberculosis.
Source: Israel Journal of Health Policy Research - Category: International Medicine & Public Health Source Type: research
Tuberculosis (TB) is a serious and important infectious disease with higher mortality and morbidity for transplantation.1-6 Most TB is considered to cause by reactivation of latent tuberculosis infection (LTBI) among solid-organ transplant recipients.2,3 For diagnosing LTBI, Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs); QuantiFERON ®-TB Gold In-Tube (QFT) [QIAGEN, Gaithersburg, USA, Australia] and T-SPOT®.TB (T-SPOT) [Oxford Immunotec, Oxford, UK], are available as more accurate methods than the tuberculin skin test (TST).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
No abstract available
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: ESPID Purple Pages Source Type: research
Conclusions: In the absence of changes to other aspects of TB control, a switch to selective vaccination will result in increased cases of childhood TB. Although not considered cost-effective, selective vaccination may be preferable to no vaccination until other changes to TB control may be implemented to reduce the risk of TB in children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Conclusions: Isoniazid did not reduce the incidence of TB in CLHIV. All included studies were performed in regions with high prevalence of TB making the overall generalizability limited.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: HIV Reports Source Type: research
Despite post-summit detente, ongoing sanctions are keeping lifesaving medicines from North Korean tuberculosis patients and could fan a regional epidemic
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
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