J & J, Macleods in talks for licence deal of tuberculosis drug

The talks, which are in early stage, will allow Macleods to manufacture generic version of the drug, a move if goes through will improve access to this new TB drug.
Source: The Economic Times - Category: Consumer Health News Source Type: news

Related Links:

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research
Tropical Medicine&International Health,Volume 0, Issue ja, -Not available-.
Source: Tropical Medicine and International Health - Category: Tropical Medicine Authors: Source Type: research
Authors: Arockiaraj J, Robert M, Rose W, Amritanand R, David KS, Krishnan V Abstract Study Design: Retrospective case series. Purpose: The aim of the study is to report the clinical characteristics, early diagnosis, management, and outcome of children with multidrug-resistant (MDR) tubercular spondylodiscitis and to assess the early detection of rifampicin resistance using the Xpert MTB/ RIF assay. Overview of Literature: MDR tuberculosis is on the rise, especially in developing countries. The incidence rate of MDR has been reported as 8.9% in children. Methods: A retrospective study of children aged
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 17 October 2018Source: Journal of Structural BiologyAuthor(s): Nebojša Bogdanović, Lavanya Sundararaman, Neelagandan Kamariah, Anu Tyagi, Shashi Bhushan, Priya Ragunathan, Joon Shin, Thomas Dick, Gerhard GrüberAbstractThe Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase (α3:β3:γ:δ:ε:a:b:b’:c9) is an essential enzyme that supplies energy for both the aerobic growing and the hypoxic dormant stage of the mycobacterial life cycle. Employing the heterologous F-ATP synthase model system αchi3:β3:γ we showed previously, that tr...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Publication date: Available online 17 October 2018Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Karade Sharanbasappa Shrimant, Shilpika Pandey, Ahmadullah Ansari, Swetarka Das, Sarita Tripathi, Ashish Arora, Sidharth Chopra, J. Venkatesh Pratap, Arunava DasguptaAbstractThe availability of complete genome sequence of Mycobacterium tuberculosis has provided an important tool to understand the mycobacterial biology with respect to host-pathogen interaction, which is an unmet need of the hour owing to continuous increasing drug resistance. Hypothetical proteins are often an overlooked pool tho...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Condition:   HIV and Tuberculosis Co-infection Interventions:   Dietary Supplement: Food basket;   Dietary Supplement: Ready-to-Use Therapeutic Food Sponsors:   University of Washington;   La Clinique des Maladies Infectieuses, Centre Hospitalier National Universitaire de Fann Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study identified a significant association between HIV infection and complexities of treating patients with tuberculosis coinfection.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Despite evidence that transmission is driving an extensively drug-resistant TB (XDR-TB) epidemic, our understanding of where and between whom transmission occurs is limited. We sought to determine whether there was genomic evidence of transmission between individuals without an epidemiologic connection. We conducted a prospective study of XDR-TB patients in KwaZulu-Natal, South Africa, during the 2011–2014 period. We collected sociodemographic and clinical data, and identified epidemiologic links based on person-to-person or hospital-based connections. We performed whole-genome sequencing (WGS) on the Mycobacterium t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Tuberculosis Source Type: research
Tuberculosis (TB) transmission often occurs within a household or community, leading to heterogeneous spatial patterns. However, apparent spatial clustering of TB could reflect ongoing transmission or co-locat...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
This open access paper reviews the interactions between cellular senescence, autophagy, and immunosenescence, with chronic infection as a mediating mechanism. Given the present state of knowledge and biotechnology, it is challenging enough to look at any two aspects of the aging body and consider how they might interact in isolation, but this can only ever be a thin slice of the bigger picture. All systems and states in our biochemistry interact with one another in some way, directly or indirectly, and examining ever larger sets of relationships between greater numbers of systems and states is the path to greater understan...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
More News: Health | Tuberculosis