J & J, Macleods in talks for licence deal of tuberculosis drug
The talks, which are in early stage, will allow Macleods to manufacture generic version of the drug, a move if goes through will improve access to this new TB drug.
ConclusionsWe observed a significant relationship between mining tenure and emphysema severity among South African miners in PATHAUT between 1975 and 2014. This relationship was evident in multi-variable analyses adjusted for smoking among white miners. Hazards from long term exposure to inhaled mineral dust leading to lung damage (silicosis, fibrosis, COPD) is evident and warrants further improvement of working conditions and prevention measures in South African mines especially for black workers. Further research is needed to determine if there is an effect of TB and HIV co-infection on the development of emphysema.
Authors: Milford C, Greener LR, Beksinska M, Greener R, Mabude Z, Smit J Abstract In South Africa, a lack of integration between sexual and reproductive health (SRH) and HIV services has led to lost opportunities in the treatment cascade. In a context of high HIV, tuberculosis (TB) and unplanned pregnancies, a model for integrating SRH and HIV services was implemented in a hospital and six feeder clinics in KwaZulu-Natal, South Africa. Changes in healthcare provider knowledge, attitudes and understandings were explored following model implementation. Baseline data were collected via focus group discussions (FGDs) a...
CONCLUSION: Despite contacts being well documented, child contacts were poorly identified. The fall-out of children at each step from identification to IPT completion was unacceptably high. Contacts of male patients and retreatment index patients were at greater risk of poor management. Recommendations to improve IPT delivery at national and local level include a review of the national IPT guidelines, considering the relative success of shorter courses of TB prophylaxis, the use of standardised IPT stationery, staff training and the involvement of community health workers in contact management. PMID: 30004366 [PubMed - in process]
Authors: Allwood BW, Maarman GJ, Kyriakakis CG, Doubell AF PMID: 30004336 [PubMed - in process]
ConclusionThis report describes cross-transmission ofMycobacterium tuberculosis from non-citizens MOHA to Israeli citizens who were residents of a nursing home, which may be the first sign for an epidemiological shift. Although cross-ethnical transmission is still rare in Israel, medical settings should employ efficient infection control measures to protect both patients and staff fromMycobacterium tuberculosis.
Tuberculosis (TB) is a serious and important infectious disease with higher mortality and morbidity for transplantation.1-6 Most TB is considered to cause by reactivation of latent tuberculosis infection (LTBI) among solid-organ transplant recipients.2,3 For diagnosing LTBI, Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs); QuantiFERON ®-TB Gold In-Tube (QFT) [QIAGEN, Gaithersburg, USA, Australia] and T-SPOT®.TB (T-SPOT) [Oxford Immunotec, Oxford, UK], are available as more accurate methods than the tuberculin skin test (TST).
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Conclusions: In the absence of changes to other aspects of TB control, a switch to selective vaccination will result in increased cases of childhood TB. Although not considered cost-effective, selective vaccination may be preferable to no vaccination until other changes to TB control may be implemented to reduce the risk of TB in children.
Conclusions: Isoniazid did not reduce the incidence of TB in CLHIV. All included studies were performed in regions with high prevalence of TB making the overall generalizability limited.
Despite post-summit detente, ongoing sanctions are keeping lifesaving medicines from North Korean tuberculosis patients and could fan a regional epidemic