Dogs that could stop men dying by sniffing out prostate cancer

Prostate cancer now kills more men than breast cancer does women - but there's a huge gender health gap. Here, medical detection dogs could prove a game-changer for all involved.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionsA substantial proportion of men with PCA unselected for metastatic disease carry germline DNA repair PVs. Breast cancer family history and high Gleason score are important predictors to identify men with PCA who may carry germline DNA repair PVs. Our findings support current NCCN guidelines and have implications for genetic assessment, therapeutic management, and cascade testing for men with PCA and their families.
Source: The Prostate - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Abstract The interaction between pituitary hormones, GH - PRL, and Growth Factors, GF, plays a fundamental role in the physiological and neoplastic mechanisms of growth, the latter using these factors to a much greater extent compared to the former, with a direct dose-dependent effect on the speed of local or metastatic expansion. In hormone-dependent tumours, the respective male and female sex hormones interact with GH - PRL - GF to sustain the expansion of the tumour. We carried out a review of the literature on the relationship between the expression of GH and GHR in tumour tissues compared to healthy ...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Publication date: Available online 6 November 2018Source: Journal of Bone OncologyAuthor(s): Stella D'Oronzo, Robert Coleman, Janet Brown, Francesco SilvestrisAbstractBone metastases (BM) are a common complication of cancer, whose management often requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with BM may still experience skeletal-related events and symptomatic skeletal events, with detrimental impact on quality of life and survival.A deeper knowledge of the mechanisms underlying the onset of lytic and sclerotic BM has been acquired in the last decades, leading to the development o...
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Abstract Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72.5 ± 13.1 years, and the age of the patients without cancer was 72.5 ± 12.8 years. The number of male cancer survivors was sign...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Med Res Source Type: research
To the Editor: We thank Professor Spratt for his editorial, which accompanied publication of our manuscript that assessed Ki67 as a prognostic and predictive biomarker after radiation therapy in localized prostate cancer (1, 2). The editorial mentions a rather small increase in biochemical recurrence per unit increase in Ki67, which warrants clarification. We assessed Ki67 as a continuous variable using a percentage scale, as recommended in both the Transparent Reporting of a Multivariate Prediction Model for Individual Prognosis or Diagnosis statement (3) and recent literature relating to optimal use of Ki67 in breast cancer (4).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
AbstractThe past decade has witnessed a growing role and increasing use of whole-body magnetic resonance imaging (WB-MRI). Driving these successes are developments in both hardware and software that have reduced overall examination times and significantly improved MR imaging quality. In addition, radiologists and clinicians have continued to find promising new applications of this innovative imaging technique that brings together morphologic and functional characterization of tissues. In oncology, the role of WB-MRI has expanded to the point of being recommended in international guidelines for the assessment of several can...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Conclusiones: El tratamiento de la OMAM depende del estadio de la enfermedad; la mandibulectomía es un tratamiento efectivo en el estadio 3 y la secuestrectomía en el estadio 2; el estadio 1 suele controlarse con tratamiento conservador.ABSTRACT Introduction: Bisphosphonates are a family of drugs used to inhibit bone resorption. One of their secondary effects is osteonecrosis of the jaws (ONJ). In 2010, scientists began to publish cases of osteonecrosis of the jaws associated with a new drug, denosumab. In 2014 it was recommended to change the name of ONJ to medication-related osteonecrosis of the jaws (MONJ)...
Source: Revista Espanola de Cirugia Oral y Maxilofacial - Category: ENT & OMF Source Type: research
Conclusion - This study suggests the possible involvement of DDC expression in Docetaxel and Mitoxantrone-induced cytotoxicity and apoptosis. PMID: 30417785 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research
Conclusion: PFKFB4 promotes the metastasis of breast cancer cells via induction of HAS2 expression and HA production in a p38-dependent manner. Therefore, the PFKFB4/p38/HAS2 signaling pathway may serve as a potential therapeutic target for metastatic breast cancer.Cell Physiol Biochem 2018;50:2108 –2123
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
The objective of this study was to determine whether Medicare Shared Savings Program (MSSP) ACO enrollment was associated with changes in screening for breast, colorectal, and prostate cancers.MethodsThe authors built a cohort of Medicare beneficiaries from 2006 through 2014 comprising 39,218,652 person ‐years of observation before and 17,252,345 person‐years of observation after MSSP enrollment. The Centers for Medicare&Medicaid Services attribution methodology was recapitulated; and screening services were identified for breast, colorectal, and prostate cancer, implementing both sensitive and specific definitions...
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
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