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DIY cystitis therapy could end misery for thousands of women

From the age of 15, Mia Elderkvist suffered from repeated urinary tract infections which blighted her life. But a simple way of administering treatment changed her life.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E.coli) have become a serious health concern worldwide due to their multidrug-resistance with seriously limiting therapeutic options. There were numerous studies on risk factors for development of ESBL-producing E.coli; however the long-term ultimate f ate of UTIs caused by ESBL-producing E.coli remains unknown. Thus, here in we longitudinally monitored female patients with UTIs due to ESBL-producing E.coli and evaluated the recurrence rate and causative organism once UTI recurred during follow up.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II Source Type: research
Acute, uncomplicated urinary tract infection (UTI) remains one of the most common bacterial infections seen in inpatient and outpatient clinical settings in the United States. Since uncomplicated UTI is treated in a variety of different settings, guidelines from professional medical societies are expected to be well aligned. Our aim was to compare guidelines for diagnosis and treatment of acute, uncomplicated UTI from medical specialties in the U.S. and confirm uniformity.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II Source Type: research
ConclusionThis large case series demonstrates that patients with chronic LUTS and pyuria experience symptom regression and a reduction in urinary tract inflammation associated with antimicrobial therapy. Disease regression was achieved with a low frequency of AEs. These results provide preliminary data to inform a future randomized controlled trial (RCT).
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
Conclusion: In accordance with the global antibiotic stewardship initiative and considering new insights in scientific research, we updated our German clinical UTI guideline to promote a responsible antibiotic use and to give clear hands-on recommendations for the diagnosis and management of UTIs in adults in Germany for healthcare providers and patients.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
AbstractBackgroundMultidrug-resistant Gram-negative bacteria have emerged as major clinical and therapeutic dilemma in hospitals in Ghana.To describe the prevalence and profile of infections attributable to multidrug-resistant Gram-negative bacteria among patients at the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana.MethodsBacterial cultures were randomly selected from the microbiology laboratory from February to August, 2015. Bacterial identification and minimum inhibitory concentrations were conducted using standard microbiological techniques and the Vitek-2 automated system. Patient information was retri...
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Urinary tract infections (UTIs) are the most common bacterial infections seen in the community, especially amongst females. The widespread use of antibiotics has led to the increased occurrence of E. coli resistant isolates worldwide. A promising non-antibiotic approach is the use of probiotic lactobacilli strains. This paper hypothesizes that Lactobacillus spp. containing products are able to prevent recurrent urinary tract infections in females. Using the keywords [lactobacillus OR lactobacilli OR probiotic] and [urinary tract infection OR UTI OR cystitis], a preliminary search on the PubMed, Ovid, Google Scholar and Cli...
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research
The signaling networks regulating antimicrobial activity during urinary tract infection (UTI) are incompletely understood. Interleukin-6 (IL-6) levels increase with UTI severity, but the specific contributions of IL-6 to host immunity against bacterial uropathogens are unknown. To clarify this we tested whether IL-6 activates the Stat3 transcription factor, to drive a program of antimicrobial peptide gene expression in infected urothelium during UTI. Transurethral inoculation of uropathogenic Escherichia coli led to IL-6 secretion, urothelial Stat3 phosphorylation, and activation of antimicrobial peptide transcription, in ...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research
CONCLUSIONS: Antimicrobial treatment for ESBL-producing UTI greatly varies, and carbapenems are excessively prescribed. Specific guidelines for ESBL infections are required. PMID: 29449049 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: 30 May 2018 Source:Biosensors and Bioelectronics, Volume 106 Author(s): Juan Gomez-Cruz, Srijit Nair, Angel Manjarrez-Hernandez, Sandra Gavilanes-Parra, Gabriel Ascanio, Carlos Escobedo Rapid, inexpensive and sensitive detection of uropathogenic Escherichia coli (UPEC), a common cause of ascending urinary tract infections (UTIs) including cystitis and pyelonephritis, is critical given the increasing number of cases and its recurrence worldwide. In this paper, we present a label-free nanoplasmonic sensing platform, built with off-the-shelf optical and electronic components, which can detect intact UPEC at...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Authors: Kalinderi K, Delkos D, Kalinderis M, Athanasiadis A, Kalogiannidis I Abstract Urinary tract infections (UTIs) are the most common bacterial infection in pregnancy, increasing the risk of maternal and neonatal morbidity and mortality. Urinary tract infections may present as asymptomatic bacteriuria, acute cystitis or pyelonephritis. Escherichia coli is the most common pathogen associated with both symptomatic and asymptomatic bacteriuria. If asymptomatic bacteriuria is untreated, up to 30% of mothers develop acute pyelonephritis, with an increased risk of multiple maternal and neonatal complications, such a...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
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