Skin cancer calculator can determine your risk of melanoma

Melanoma is the fifth most common cancer in the UK. Figures suggest it kills nearly 2,500 people across the home nations each year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 19 February 2019Source: Nitric OxideAuthor(s): Joicy S. dos Santos, Loyanne C. Ramos, Lucimara P. Ferreira, Vanessa Campos, Lucas C.D. de Rezende, Flávio da Silva Emery, Roberto Santana da SilvaAbstractThis work investigates how the luminescent ruthenium-nitrite complexes cis-[Ru(py-bodipy)(dcbpy)2(NO2)](PF6) (I) and cis-[Ru(py-bodipy)(dcbpy-aminopropyl-β-lactose)2(NO2)](PF6) (II) behave toward the melanoma cancer cell line B16F10. The chemical structure and purity of the synthesized complexes were analyzed by UV-Visible and FTIR spectroscopy, MALDI, HPLC, and 1H NMR. Spectrof...
Source: Nitric Oxide - Category: Chemistry Source Type: research
Authors: Liu P, Du R, Yu X Abstract BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. MATERIAL AND METHODS WST-1 and colony formation assays were used for cell viability assessment. Cell cycle analysis was performed by flow cytometry. Apoptosis was detected by AO/EB staining using fluorescence microscopy. Cell migration and inv...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
(Johns Hopkins Medicine) Study shows new forms of an older anti-cancer agent appear to enhance the immune system's ability to fight melanoma in mice.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In this study, we developed a Component Overlapping Attribute Clustering (COAC) algorithm to perform the localized (subpopulation) gene co-expression network analysis from large-scale scRNA-seq profiles. Gene subnetworks that represent specific gene co-expression patterns are inferred from the components of a decomposed matrix of scRNA-seq profiles. We showed that single-cell gene subnetworks identified by COAC from multiple time points within cell phases can be used for cell type identification with high accuracy (83%). In addition, COAC-inferred subnetworks from melanoma patients’ scRNA-seq profiles are highly corr...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
AbstractWe used four-color ImmunoSpot ® assays, in conjunction with peptide pools that cover the sequence of tyrosinase (Tyr), melanoma-associated antigen A3 (MAGE-A3), melanocyte antigen/melanoma antigen recognized by T cells 1 (Melan-A/MART-1), glycoprotein 100 (gp100), and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) to characterize the melanoma antigen (MA)-specific CD8 + cell repertoire in PBMC of 40 healthy human donors (HD). Tyr triggered interferon gamma (IFN-γ)-secreting CD8 + T cells in 25% of HD within 24 h of antigen stimulation ex vivo. MAGE-A3, Melan-A/MA...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
AbstractPurposeWe have previously developed the caspase-based radiotracer,18F-ICMT-11, for PET imaging to monitor treatment response. We further validated18F-ICMT-11 specificity in a murine melanoma death-switch tumour model with conditional activation of caspase-3 induced by doxycycline.MethodsCaspase-3/7 activity and cellular uptake of18F-ICMT-11,18F-ML-10 and18F-FDG were assessed in B16ova and B16ovaRevC3 cells after death-switch induction.Death-switch induction was confirmed in vivo in xenograft tumours, and18F-ICMT-11 and18F-ML-10 biodistribution was assessed byex vivo gamma counting of select tissues. PET imaging was...
Source: EJNMMI Research - Category: Radiology Source Type: research
The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein–coupled receptors (GPCRs) to control downstream events, such as cell motility and gene transcription. This conserved signal transduction axis is crucial for tumor growth in uveal melanoma. Previous studies indicate that the GEF activity of the TrioC module is autoinhibited, with release of autoinhibition upon Gαq/11 binding. Here, we determined the crystal structur...
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Articles Source Type: news
In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)-1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Condition:   Cutaneous Melanoma Interventions:   Behavioral: Demographics Questionnaire;   Behavioral: Adjuvant Treatment Beliefs Scale10;   Behavioral: Functional Assessment of Cancer Therapy - Melanoma (FACT-M)11;   Behavioral: Functional Assessment of Chronic Illness Therapy - Treatment Satisfaction - General (FACIT-TS-G)13;   Beh avioral: Decisional Regret14 Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Zhang J, Zhang H, Luo Y Abstract BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. RESULTS The positive expression rate of PD-1 in sPD-1 and T cells of patients with cancer pain was higher than that in nor...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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