WHO Adds'Disease X' to List of Potential Pandemic Killers WHO Adds'Disease X' to List of Potential Pandemic Killers

A serious worldwide threat could erupt from an as-yet-unknown pathogen, the WHO warns. Prioritizing'X'on the annual blueprint is meant to encourage more crosscutting research and development.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

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In this study, we characterized the pathogenicity of AB14 (H5N1) and BC15 (H7N9) and found that both strain isolates are highly lethal in mice. AB14 (H5N1) caused systemic viral infection and erratic proinflammatory cytokine gene expression in different organs. In contrast, BC15 (H7N9) replicated efficiently only in the respiratory tract, and was a potent inducer for proinflammatory cytokine genes in the lungs. Our study provides experimental evidence to complement the specific human case reports and animal models for evaluating vaccine and antiviral candidates against potential influenza pandemics.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Conclusion: Rheumatology and internal medicine patients, including patients treated with methotrexate without corticosteroids, are at risk of developing chronic HEV infection. Rheumatology and internal medicine patients with abnormal liver tests should be screened for HEV infection.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
acute;nez-Sobrido Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza vaccines (IIV) or live-attenuated influenza vaccines (LAIV) remains the main strategy in the control of annual seasonal epidemics, but it does not offer protection against new influenza viruses with pandemic potential, those that have shifted. Moreover, the continual antigenic drift of seasonal circulating influenza viruses, causing an antigenic mismatch that requires yearly reformulation of seasona...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Source: World Health Organization (WHO). Published: 2/21/2019. This 10-page document summarizes the genetic and antigenic characteristics of recent zoonotic influenza viruses and related viruses circulating in animals that are relevant to influenza candidate vaccine virus updates. Zoonotic influenza viruses continue to be identified and evolve both genetically and antigenically, leading to the need for additional candidate vaccine viruses for pandemic preparedness purposes. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
hito Atsumi Numerous dietary recommendations have been made for the prevention and treatment of diabetes. However, many people with diabetes regard healthy dietary behavior as wearisome and have difficulty adhering to nutrition therapy. We, therefore, conducted a questionnaire survey concerning the restaurants that serve meals suitable for people with diabetes. We first aimed to determine the number of restaurants that were aware of the need to create special menus for people with diabetes. Second, we aimed to encourage restaurants’ serving of tasty, healthy food and promote easier social living for people wi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
(Natural News) A new report is urging government officials to begin stockpiling antibiotics in preparation for a potential global influenza pandemic, claiming that doing so will ultimately end up saving authorities tens of billions of dollars. The first study yet to model the financial value of stockpiling antibiotics, the analysis claims that the world can...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This Nigerian doctor might just prevent the next deadly pandemic, Published online: 20 February 2019; doi:10.1038/d41586-019-00615-xAs leader of the Nigeria Centre for Disease Control, Chikwe Ihekweazu works to protect the nation — and the world — from devastating outbreaks.
Source: Nature AOP - Category: Research Authors: Source Type: research
As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, developme...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
ahesh Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to public health. Treatment options are limited and emergence of strains resistant to antiviral drugs jeopardize this even further. Like all viruses, IAVs depend on host factors for every step of the virus replication cycle. Host kinases link multiple signaling pathways ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Introduction: HIV (human immunodeficiency virus) infection is the typical example of an emergent disease with an explosive pandemic evolution. HAART therapy (highly active antiretroviral therapy) dramatically influenced AIDS evolution, reducing the incidence of associated diseases and also its mortality.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Session 03 – Ultrasound and prenatal diagnosis Source Type: research
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