Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout

New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research

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Authors: Robinson PC, Dalbeth N Abstract INTRODUCTION: Febuxostat is a potent non-purine selective xanthine oxidase inhibitor approved by the FDA in 2009 for management of hyperuricemia in people with gout. Areas covered: The authors summarize the pre-clinical studies and pivotal randomized controlled trials of febuxostat when used as a treatment for hyperuricaemia in gout Expert opinion: Febuxostat has clinical efficacy in serum urate lowering, and long-term use leads to improved outcomes such as gout flare frequency and tophus burden. Recently published post-approval placebo-controlled trials have demonstrated ur...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: August 2018Source: Annals of Emergency Medicine, Volume 72, Issue 2Author(s): Joseph W. Watkins, Rawle A. Seupaul
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
(MedPage Today) -- The risk was increased by more than 70% in a Medicare cohort
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
Authors: Liu H, He J, Zhong J, Zhang H, Zhang Z, Liu L, Huang Z, Wu Y, Jiang L, Guo Z, Xu R, Chai W, Huo G, Sun X, Cheng C Abstract Background: As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke. Because the potential protective effects of UA in traumatic brain injury (TBI) remain largely unknown, this study investigated the role of UA in TBI in both clinical patients and experimental animals. Methods: In TBI patients, serum UA concentrations were measured within 3 days after injury...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Andrea Di Matteo, Emilio Filippucci, Edoardo Cipolletta, Matteo Ausili, Victoria Martire, Marco Di Carlo, Fausto Salaffi, Walter GrassiAbstractObjectivesTo determine the prevalence of the ultrasound findings indicating monosodium urate crystal deposits at the popliteal groove region in patients with gout; to evaluate the diagnostic accuracy of ultrasound in detecting monosodium urate crystal deposits at the popliteal groove region, patellar tendon and the knee hyaline cartilage; to investigate the correlation between the ultrasound findings a...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Anthony Chapron, Typhaine Chopin, Maxime Esvan, Ea Hang-Korng, Frédéric Lioté, Pascal GuggenbuhlAbstractObjectivesGout management includes non-pharmacological measures (NPM). The main objective of this study was to describe the NPM proposed by physicians and their implementation by patients after 3-6 months. The secondary objective was to identify NPM compliance profiles among these patients.MethodsAncillary observational study using the GOSPEL French cohort of 1003 patients with gout, based on questionnaires for physicia...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Chia-wei Liang, Mohaimenul Islam, Tahmina Nasrin Poly, Hsuan-ChiaYang, Yu-Chuan Li Jack
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Abstract The aims of this study were to determine the prevalence of MRI abnormalities which were suspected as sinusitis in community-dwelling middle-aged and elderly Japanese and to identify risk factors for the MRI abnormality. Brain magnetic resonance imaging (MRI) data from the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) were used for the analysis. Among the 2330 subjects in the NILS-LSA, 1933 participants were categorized as having no MRI abnormality or MRI abnormality using the Lund-Mackay (LM) score. The mean LM score of the participants was 0.88±1.92, and 144 (7....
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In the past nine years, visits to the emergency department by gout patients have increased by almost 27%. Researchers suggest physicians may not adequately be addressing the burden of gout and the underlying accumulation of uric acid, driving the dramatic increase in emergency department visits in the U.S...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis Source Type: research
(MedPage Today) -- Current view focuses on the mobilization flare hypothesis
Source: MedPage Today Rheumatology - Category: Rheumatology Source Type: news
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