Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout

New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research

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FRIDAY, Feb. 22, 2019 -- The gout medicine Uloric (febuxostat) carries a higher risk of death than allopurinol, according to the U.S. Food and Drug Administration. The agency said its in-depth review of results from a safety clinical trial found...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Febuxostat should be reserved for patients with gout-related hyperuricemia for whom allopurinol has failed or who do not tolerate allopurinol, owing to an increased risk for death, the FDA says.News Alerts
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Rheumatology News Alert Source Type: news
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Gout Drug Uloric Increases Risk of Death: FDA The gout medicine Uloric (febuxostat) carries a higher risk of death than another gout medicine...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(MedPage Today) -- Black box warning, second-line use being required
Source: MedPage Today Public Health - Category: American Health Source Type: news
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Source Type: news
Emma Stone rushes to Queen Olivia Colman ’s side when she has a flare of gout.  Winner of the Royal Rash category, learn more about this painful condition whose rate is on the rise. And take a look at runner-up Margot Robbie ’s Queen Elizabeth afflicted by smallpox. See it all only at Skinema.com...
Source: Skinema, dermatology in the media blog - Category: Dermatology Authors: Tags: Film Health Source Type: blogs
Conditions:   Organic, Including Symptomatic, Mental Disorders;   Substance Use;   Schizophrenia;   Mood [Affective] Disorders;   Neurotic, Stress-related and Somatoform Disorders;   Eating Disorder;   Disorders of Adult Personality and Behavior;   Mental Retardation;   Disorder of  Psychological Development;   Behavioural Disorder;   Hypertension;   Dyslipidemias;   Ischemic Heart Disease;   Atrial Fibrillation;   Heart ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractBackgroundHeart failure (HF) and non-cardiac comorbidities often coexist and are known to have an adverse effect on outcome. However, the prevalence and prognostic impact of non-cardiac comorbidities in patients with HF with reduced ejection fraction (HFrEF) vs. those with preserved (HFpEF) remain inadequately studied.Methods and resultsWe used data from the Swedish Heart Failure Registry from 2000 to 2012. HFrEF was defined as EF  
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Abstract Coenzyme A (CoA) is an indispensable cofactor in all living organisms. It is synthesized in an evolutionarily conserved pathway by enzymatic conjugation of cysteine, pantothenate (Vitamin B5), and ATP. This unique chemical structure allows CoA to employ its highly reactive thiol group for diverse biochemical reactions. The involvement of the CoA thiol group in the production of metabolically active CoA thioesters (e.g. acetyl CoA, malonyl CoA, and HMG CoA) and activation of carbonyl-containing compounds has been extensively studied since the discovery of this cofactor in the middle of the last century. We...
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Tags: Biochem Soc Trans Source Type: research
Conclusion: Our results indicate that detecting monosodium urate crystals by ultrasound is common at hip joint in patients with gout.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
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