The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system

ConclusionsCGRP and other big molecules cannot easily pass the blood-brain barrier. These molecules may act in the trigeminal ganglion to influence the production of pronociceptive substances and receptors, which are transported along the central terminals into the spinal trigeminal nucleus. In this way peripherally acting therapeutics can have a central antinociceptive effect.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research