Closed-Loop Neuropharmacology For Epilepsy: Distant Dream Or Future Reality?

Closed-Loop Neuropharmacology For Epilepsy: Distant Dream Or Future Reality? Curr Neuropharmacol. 2018 Mar 08;: Authors: Aicua-Rapun I, Andre P, Novy J Abstract Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment however is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment. PMID: 29521237 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research