Identification of enzymes responsible for dantrolene metabolism in the human liver: a clue to uncover the cause of liver injury.
In conclusion, we found that AOX1 and NAT2 were responsible for dantrolene metabolism in humans and that AOX1-dependent metabolism determines dantrolene-induced liver injury.
PMID: 29522712 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Amano T, Fukami T, Ogiso T, Hirose D, Jones JP, Taniguchi T, Nakajima M Tags: Biochem Pharmacol Source Type: research
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