Indomethacin administered early in the postnatal period results in reduced glomerular number in the adult rat.

Conclusions: Indomethacin administered during glomerulogenesis appears to reduce the number of glomeruli in adulthood. Alternative options for closing a PDA should be considered including ibuprofen as well as emerging therapies such as paracetamol.
PMID: 25186294 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - September 3, 2014 Category: Urology & Nephrology Authors: Kent AL, Koina ME, Gubhaju L, Cullen-McEwen LA, Bertram JF, Lynnhtun J, Shadbolt B, Falk MC, Dahlstrom JE Tags: Am J Physiol Renal Physiol Source Type: research