Menopause in CKD
Publication date: Available online 9 March 2018 Source:American Journal of Kidney Diseases Author(s): Kavitha Vellanki, Susan Hou Most women with dialysis-dependent chronic kidney disease (CKD) stage 5 (CKD stage 5D) are in the postmenopausal age group. Early menopause is reported for all CKD stages (stages 3-5D). The traditional definition of menopause is not applicable in CKD stage 5(D) because menses can resume with hormone replacement therapy or kidney transplantation. Treatment of vasomotor symptoms continues to be the primary indication for hormone replacement therapy, with no dosing studies done specifically for CKD or kidney transplantation populations. Similarly, the risk for cardiovascular disease and osteoporosis in menopause is well described in healthy women, but the role that menopause plays in accelerating the risk further in CKD/kidney transplantation is yet to be explored. Lack of data and specific guidance on management make the long-term effects of menopause one of the most under-recognized and neglected patient problems in clinical nephrology. The efficacy and side effects of widely available therapeutic options in healthy women for menopause-related clinical manifestations, be it hormone replacement therapy for vasomotor symptoms or antiresorptive agents for osteoporosis, are to be tested in kidney transplantation and CKD populations. Longitudinal clinical trials are in need to define menopause in CKD and determine the role that CKD plays in menopause tr...
The U.S. Supreme Court on Monday gave Merck&Co a new opportunity to avoid lawsuits accusing the company of failing to properly warn patients of debilitating thigh-bone fractures from taking its osteoporosis drug Fosamax, throwing out a lower court decision that had revived the litigation.
Authors: Franco A, González Y, Balibrea N, Díaz M, Planells MC, Pérez Contreras FJ PMID: 31103245 [PubMed - as supplied by publisher]
Condition: Kidney Transplant Failure and Rejection Intervention: Drug: Everolimus Sponsor: Hospices Civils de Lyon Not yet recruiting
Conditions: Chronic Kidney Diseases; Cardiovascular Diseases; Endothelial Dysfunction Intervention: Other: [Pyr]apelin-13 Sponsors: University of Edinburgh; Kidney Cancer UK Not yet recruiting
Condition: Aplastic Anemia Idiopathic Intervention: Drug: Haploidentical HSCT using TBI free regimen, ''ATG'' with ''Post transplant cyclophosphamide'' Sponsor: Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan Recruiting
Harri Stickler is "doing great" after a donor was found following an appeal.
Adrienne Mahoney suffers from a rare autoimmune disorder that caused her heart to all but fail. She lived precipitously with a device to assist her heart's function, until it came time for a full heart transplant this year.
A phase III study tested the combination conditioning regimen of busulfan plus melphalan vs standard melphalan alone for patients with newly diagnosed multiple myeloma undergoing transplantation.
ConclusionAdvances have been more prominent in cases of auditory neuropathy, since partial improvement of auditory nerve conditions through cell-based therapy may increase the number of patients who can successfully receive cochlear implants.ResumoIntroduçãoCélulas ciliadas de mamíferos e neurônios auditivos não apresentam capacidade regenerativa. Assim, os danos a esses tipos de células são permanentes, levam à perda auditiva, e não há tratamento que restabeleça a função auditiva. Terapias regenerativas utilizando célul...
Publication date: Available online 18 May 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Ricardo Lorenzoni, Fabiano Barreto, Renata Vidor Contri, Bibiana Verlindo de Araújo, Adriana Raffin Pohlman, Teresa Dalla Costa, Silvia Stanisçuaski GuterresAbstractA bioanalytical LC-MS/MS method was developed and validated for the simultaneous quantification of capsaicin (CAPS) and dihydrocapsaicin (D-CAPS) in dermal microdialysis samples from rats. Capsaicinoids were separated by using a C18 column, with a mobile phase of water and acetonitrile, both with 0.1% of formic acid, eluted as a gradie...