Mitochondria: A Connecting Link In The Major Depressive Disorder Jigsaw.

CONCLUSION: Mitochondria are integral to the function of neurons and undergo dysfunction in major depressive disorder patients. This dysfunction is reflected in all the various hypotheses that have been proposed for depression. Among the newer targets identified, which also involve mitochondria, includes the role of exogenous ATP. The diversity of purinergic receptors, and their differential expression among various individuals in the population, due to genetic and environmental (prenatal) influences, may influence the susceptibility and severity of depression. Identifying specific receptors involved and using patient-specific purinergic receptor antagonist may be an appropriate therapeutic course in the future. PMID: 29512466 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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Packed with iron, iodine, vitamin B12, vitamin D, folate and choline, the rich nutritional composition of eggs means that they can supply most of the key nutrients required during pregnancy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jee Su Suh, Maiko Abel Schneider, Luciano Minuzzi, Glenda M. MacQueen, Stephen C. Strother, Sidney H. Kennedy, Benicio N. FreyAbstractNeuroimaging studies assessing neurobiological differences between patients with major depressive disorder (MDD) and healthy controls (HC) are often hindered by small sample sizes and heterogeneity of the patient sample. We performed a comprehensive literature search for studies assessing cortical thickness between patient and control groups, including studies inv...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
In this study, we investigated brain activation in suicidal and non-suicidal patients with MDD during facial emotion processing and executive control. Functional magnetic resonance imaging (fMRI) data from the NESDA-fMRI study (MDD patients N = 103, healthy controls N = 26, HC) were analyzed. Patients were divided in a group of suicide attempters (N = 18, SA), suicide ideators (N = 31, SI) and a patient-control group (N = 73, PC). A gender discrimination task with emotional faces and the Tower of London executive planning task were investigated. An ANOVA was performed to co...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 15 August 2018Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Jacqueline E. Cheyne, Andrea del Pozo de Bolger, Bethany M. WoottonAbstractTrichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. The Trichotillomania Dimensional Scale (TTM-D) is a newly developed DSM-5 scale that aims to assess the symptoms of TTM dimensionally. The aim of this current study was to examine the psychometric properties of the TTM-D in a sample of 483 participants. Principal Component Analysis indicated a single factor structure of the TTM-D. Internal c...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Researchers from Ohio State University also found that hostile married couples are more at risk of leaky guts and inflammation if one of the spouses has a history of depression.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In conclusion, CF is associated with poorer QOL in childhood. In order to improve quality of life in CF, the psychiatric conditions of children and adolescents should also be evaluated and their follow-up and treatment should involve a multidisciplinary team approach. PMID: 30102477 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
INTRODUCTION: Previous research has found mixed results when assessing the association between a parent's history of depressive symptoms and a child's abilities on measures of executive functioning. The purpose of this study was to replicate and expand upo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Suicide in the United States continues to be a pervasive problem with military veterans. Sadly, effects of previous military service continue to plague many elderly military veterans decades after the war. Many years after the war, some aging elderly veter...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Features that enhance neighborhood walkability (higher population density, street connectivity and access to destinations) are associated with higher levels of physical activity among older adults. The perceived neighborhood environment appears to mediate ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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