fMRI offers clues about memory loss in older adults

Functional MRI (fMRI) offers clues as to which memory lapses in older adults...Read more on AuntMinnie.comRelated Reading: fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus MRI shows brain changes after 1 season of youth football
Source: Headlines - Category: Radiology Source Type: news

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Publication date: Available online 16 November 2018Source: SeizureAuthor(s): Delphine TaussigAbstractDesigned from the 60 s to the 80 s for adults, and despite the development of many new techniques, invasive explorations still have indications in children with focal drug-resistant epilepsy. The main types are stereoelectroencephalography (SEEG) and subdural explorations (SDE). They provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex, and the feasibility of performing a tailored surgical resection. Thermocoagulations, which are a diagnostic an...
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 16 November 2018Source: SeizureAuthor(s): Jonathan Dallas, Dario J. Englot, Robert P. NaftelAbstractEpilepsy is a common pediatric neurological condition, and approximately one-third of children with epilepsy are refractory to medical management. For these children neurosurgery may be indicated, but operative success is dependent on complete delineation of the epileptogenic zone. In this review, surgical techniques for pediatric epilepsy are considered. First, potentially-curative operations are discussed and broadly divided into resections and disconnections. Then, two palliative approac...
Source: Seizure - Category: Neurology Source Type: research
Musician Kira Iaconetti had a form of epilepsy that was triggered by listening to or playing music.
Source: Science - The Huffington Post - Category: Science Source Type: news
Conclusion: Mutual information-defined functional connectivity captures physiologically relevant features of the brain network better than correlation. Clinical Relevance: Optimizing the capacity to predict cognitive phenotypes at the patient level is a necessary step toward the clinical utility of network-based biomarkers. PMID: 30425750 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
Long‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse. Mol Med Rep. 2018 Nov 05;: Authors: Cui W, Wang H, Cheng Y, Ma X, Lei Y, Ruan X, Shi L, Lv M Abstract Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compressed action potential amplitude, which is contradict...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
UCLA biologists have discovered how head injuries adversely affect individual cells and genes  that can lead to serious brain disorders. The life scientists provide the first cell “atlas” of the hippocampus — the part of the brain that helps regulate learning and memory — when it is affected by traumatic brain injury. The team also proposes gene candidates for treating brain disease s associated with traumatic brain injury, such as Alzheimer’s disease and post-traumatic stress disorder.The researchers studied more than 6,000 cells in 15 hippocampal cell types — the first study of in...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Authors: Mula M, Sander JW Abstract INTRODUCTION: Depression is the most frequent psychiatric comorbidity among people with epilepsy. It can impact on quality of life and increases the risk of morbidity and premature mortality. Areas covered: The authors review the available data on current and emerging drug treatments for depression in epilepsy. Sources have been identified through Medline/PubMed searches while ongoing clinical trials have been identified through a search. Expert opinion: SSRIs are the drug class with the largest amount of data. Though promising, the level of evidence provided b...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Conclusions: A PPK–pharmacogenetic model of LTG in Chinese children with epilepsy was successfully established with nonlinear mixed effects modeling. Genotyping for UGT2B7-161C>T may be useful in titrating the optimal LTG dose.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Multiple Postdoctoral research positions are available in the Tandon Lab at The University of Texas in Houston as part of the newly formed Texas Epilepsy Neurotechnologies and Neuroinformatics (TENN) Institute. Positions are funded either via multi-year Institute funding or by NIH funds (U01 and R01). The lab uses multimodal approaches – fMRI, lesional analysis following epilepsy surgery, intracranial recordings and direct stimulation to create and validate network level representations of language. Lab Collaborators include Greg Hickok (UCI), Stanislas Dehaene (NeuroSpin), Nathan Crone (JHU), Simon Fisher Baum (Rice...
Source: Talking Brains - Category: Neuroscience Authors: Source Type: blogs
GNAO1 variants were recently discovered as causes of epileptic encephalopathies and heterogeneous syndromes presenting with movement disorders (MDs), whose phenomenology and clinical course are yet undefined. We herein focused on GNAO1-related MD, providing an analytical review of existing data to outline the main MD phenomenology and management, clinical evolution and genotype-phenotype correlations.Reviewing 41 previously published patients and assessing 5 novel cases, a comprehensive cohort of 46 patients was analyzed, reassuming knowledge about genotypes, phenotypes, disease course and treatment of this condition.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Review article Source Type: research
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