fMRI offers clues about memory loss in older adults

Functional MRI (fMRI) offers clues as to which memory lapses in older adults...Read more on AuntMinnie.comRelated Reading: fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus MRI shows brain changes after 1 season of youth football
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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ConclusionWe noticed an increased utilization of eiEEG in elderly patients after the introduction of SEEG at our center. Overall, we found that eiEEG can help achieve good seizure outcomes in the elderly population. However, the one eiEEG-related mortality serves a word of caution about the potential risks in this population.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: The Lancet PsychiatryAuthor(s): René S Kahn, Inge Winter van Rossum, Stefan Leucht, Philip McGuire, Shon W Lewis, Marion Leboyer, Celso Arango, Paola Dazzan, Richard Drake, Stephan Heres, Covadonga M Díaz-Caneja, Dan Rujescu, Mark Weiser, Silvana Galderisi, Birte Glenthøj, Marinus J C Eijkemans, W Wolfgang Fleischhacker, Shitij Kapur, Iris E Sommer, René S KahnSummaryBackgroundNo established treatment algorithm exists for patients with schizophrenia. Whether switching antipsychotics or early use of clozapine improves outcome in (first-epis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 13 August 2018Source: Life SciencesAuthor(s): Yun-Li Yu, Na-Na Li, Meng-Ting Shi, Hong-Juan LuAbstractAimsChanges in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period.Main methodsA total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into this study. These patients were divided into three pairs of groups: less frequent seizure group and more frequent seizure group; medication group and non-medication group;
Source: Life Sciences - Category: Biology Source Type: research
AbstractThe endocannabinoid retrograde signaling pathway is widely expressed in the central nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and inhibitory) through long-term potentiation and long-term depression. The endocannabinoid system (ECS) components —cannabinoid receptors, endocannabinoids and synthesis/degradation enzymes—are expressed and are functional from early developmental stages and throughout adolescent cortical development, regulating progenitor cell fate, neural differentiation, migration and survival. This may potentially confer increased vulnerability...
Source: CNS Drugs - Category: Neurology Source Type: research
ConclusionsMEG played an additional and valuable role in the localisation of operculo-insular epilepsy for patients with a negative MRI finding.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): María Guadalupe Valle-Dorado, César Emmanuel Santana-Gómez, Sandra Adela Orozco-Suárez, Luisa RochaAbstractSeveral studies indicate that sodium cromoglycate (CG) induces neuroprotective effects in acute neurological conditions. The present study focused on investigating if the use of CG in rats during the post-status epilepticus (post-SE) period reduces the acute and long-term consequences of seizure activity. Our results revealed that animals that received a single dose of CG (50 mg/kg s.c.: subcutaneous...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
We examined correlates of depressive symptoms and suicidal ideation in adults using pooled data from epilepsy self-management studies conducted by sites in the Centers for Disease Control and Prevention (CDC) Research Center's Managing Epilepsy Well (MEW) Network that assessed depression severity with the 9-item Patient Health Questionnaire (PHQ-9). Of the 770 subjects in the analysis (mean age 42.4 ± 13.0 years), the mean total PHQ-9 score was 9.4 ± 6.6 and 334 subjects (43.4%) had moderate to severe depressive symptoms (PHQ-9 ≥ 10). Only ongoing seizures and low education were associated wi...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): Chao Zhang, Hongyu Yang, Chang Liu, Guojun Zhang, Nan Chen, Kuncheng LiAbstractThe aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 August 2018Source: Epilepsy &BehaviorAuthor(s): Xiaoxuan Fu, Youhua Wang, Manling Ge, Danhong Wang, Rongguang Gao, Long Wang, Jundan Guo, Hesheng LiuAbstractInterictal spike is a biomarker of epilepsy that can occur frequently between seizures. Its potential effects on brain oscillations, especially on theta rhythm (4–8 Hz) that is related to a variety of cognitive processes, remain controversial. Using local field potentials recorded from patients with temporal lobe epilepsy (TLE), we investigated here the impact of spikes on theta rhythm immediately after spikes and durin...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Sir Victor Horsley gave a landmark address to the British Medical Association on 'Advances in the Surgery of the Central Nervous System' in which he described how he had successfully inferred the seizure localization of three epilepsy surgery patients; most notably 'James B.' who suffered from post-traumatic epilepsy as a result of a depressed skull fracture following a traffic accident. Drawing on both the pioneering work of John Hughlings Jackson and his own experimental findings, Horsley was confident that James B's seizure onset occurred in the contralateral sensorimotor strip. Horsley operated to remove the cortical s...
Source: Forensic Psychology Blog - Category: Forensic Medicine Source Type: blogs
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