Repeated Ranibizumab Injections Safe in Diabetic Macular Edema Repeated Ranibizumab Injections Safe in Diabetic Macular Edema

In patients with diabetic macular edema, repeated ranibizumab injections are not associated with impaired macular perfusion and can be safely offered even to those with severe microangiopathy and advanced capillary dropout, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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CONCLUSION: Thirty days post PCI, IC tirofiban was more efficient in ameliorating blood flow in the coronary arteries and myocardial tissue perfusion in DM patients after STEMI despite bleeding events, and MACE rates showed no significant difference between the groups. The IC group showed better improvement in LVEF. PMID: 31194213 [PubMed - as supplied by publisher]
Source: Cardiovascular Journal of Africa - Category: Cardiology Authors: Tags: Cardiovasc J Afr Source Type: research
Abstract Chronic hyperglycemia is the key point of macro- and microvascular complications associated with diabetes mellitus. Excess glucose is responsible for inducing redox imbalance and both systemic and intrarenal inflammation, playing a critical role in the pathogenesis of diabetic kidney disease, which is currently the leading cause of dialysis in the world. The pathogenesis of the disease is complex, multifactorial and not fully elucidated; many factors and mechanisms are involved in the development, progression and clinical outcomes of the disease. Despite the disparate mechanisms involved in renal damage related to...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
AbstractClinical predictors for later adverse cardiovascular events in patients undergoing percutaneous coronary intervention (PCI) for silent myocardial ischemia remain undetermined. We investigated clinical features leading to later adverse cardiovascular events in patients who underwent PCI for silent myocardial ischemia. Of a total of 294 consecutive patients with a diagnosis of silent myocardial ischemia who successfully underwent contemporary PCI in our institute between January 2013 and December 2014, an initial event of any of all-cause death, hospitalized heart failure, acute coronary syndromes, and target vessel ...
Source: Heart and Vessels - Category: Cardiology Source Type: research
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 29 May 2019Source: Journal of Industrial and Engineering ChemistryAuthor(s): Hyun-Ji Park, Suna Kim, Eun Je Jeon, In-Taek Song, Haeshin Lee, Youngsook Son, Hyun Sook Hong, Seung-Woo ChoAbstractSubstance P (SP) is a therapeutic peptide that has been widely used to induce angiogenesis and tissue regeneration. However, its therapeutic efficacy is often limited due to rapid degradation in vivo and a short half-life (˜1 min) after systemic administration. In the present study, we chemically modified SP with polyethylene glycol (PEG) to generate long-lasting formulations with incre...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
This study will provide evidence for further CRA development. PMID: 31150656 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Tags: Toxicol Appl Pharmacol Source Type: research
ConclusionClassification based on congestion/perfusion status provides clinically relevant information at hospital admission and discharge. A better understanding of the clinical course of the two entities could play an important role towards the implementation of targeted strategies that may improve outcomes.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
ConclusionsIn this study, macular vessel density remained statistically unchanged following up to three intravitreal injections of any anti-VEGF agent. This indicates that there may not be an early effect of anti-VEGF treatment on macular vessel density and its effect on macular perfusion may not be a direct change in microvascular flow.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
36Objectives: In type II diabetes, glucose metabolism is compromised. This impairment is known to increase cardiac fatty acid consumption, but its effect on other substrates, such as ketones (acetoacetate and beta-hydroxybutyrate) is poorly understood. A recent study (EMPA-REG)[asterisk] evaluating the inhibition of glucose reabsorption by kidneys in type II diabetes has shown a reduction of sudden cardiac death and heart failure hospitalization. The treatment also led to a slight decrease in HbA1c and an increase in blood ketones. The aim of the present study is to use [11C]-acetoacetate as a direct index to characterize ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research
309Objectives: The significance of post-stress reduction in left ventricular ejection fraction (LVEF) in patients who underwent an adenosine stress/rest study with no evidence of reversible perfusion defects remains controversial with only few studies comprising a large number of patients. The aim of this study is to determine the prognostic value of post-adenosine stress decrease in LVEF in these patients. Materials and Methods: We have identified all patients who had a two-day adenosine stress/rest 99mTc-sestamibi scan performed between 1/2015 and 10/2017 at Jordan University Hospital, no evidence of reversible perfusion...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science: Improving Prognostication from Cardiac Nuclear Imaging Source Type: research
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