Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease.

In this study, we aimed to identify genes aberrantly regulated by STAT6 to better understand how increased IL13/STAT6 signaling may contribute to PKD progression. We demonstrate that the expression of periostin, galectin-3 and interleukin-24 (IL24) are up regulated in various forms of PKD and that their aberrant regulation is mediated by IL13 and STAT6 activity. Periostin and galectin-3 have previously been implicated in PKD progression. We support these findings by showing that periostin expression is increased after IL13 treatment in kidney epithelial cells, that galectin-3 expression is increased after injecting IL13 in vivo, and that IL24 expression is upregulated by both IL13 treatment and PC1-p30 over expression in mouse and human kidney cells. Overall, these findings provide insight into the possible mechanisms by which increased IL13/STAT6 signaling contributes to PKD progression and suggest potential therapeutic targets. PMID: 29513071 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research