Supply bottleneck impairs nerve function

(University of W ü rzburg) Impaired transport processes in neurons contribute to diseases such as amyotrophic lateral sclerosis (AML). W ü rzburg scientists have now identified key actors in these processes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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AbstractObjectiveTo evaluate the involvement of the sensory and autonomic nervous system in amyotrophic lateral sclerosis (ALS) and to determine whether TDP-43/pTDP-43 deposits in skin nerve fibers signify a valuable biomarker for ALS.MethodsEighteen patients with ALS and 18 age- and sex-matched control subjects underwent physical examinations, in addition to donating skin biopsies from the distal leg. The density of epidermal, Meissner ’s corpuscle (MC), sudomotor, and pilomotor nerve fibers were measured. Confocal microscopy was used to determine the cutaneous somatic and autonomic nerve fiber density and TDP-43/pT...
Source: Journal of Neurology - Category: Neurology Source Type: research
Conditions:   Amyotrophic Lateral Sclerosis;   ALS;   Lou Gehrig Disease;   Lou Gehrig's Disease;   Lou-Gehrigs Disease;   Motor Neuron Disease, Amyotrophic Lateral Sclerosis Intervention:   Drug: Riluzole Sponsor:   Biohaven Pharmaceutical Holding Company Ltd. Available
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Amyotrophic Lateral Sclerosis Intervention:   Other: no intervention Sponsor:   Ruxandra Iancu Ferfoglia Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Amyotrophic Lateral Sclerosis;   ALS;   Lou Gehrig Disease;   Lou Gehrig's Disease;   Lou-Gehrigs Disease;   Motor Neuron Disease, Amyotrophic Lateral Sclerosis Intervention:   Drug: Riluzole Sponsor:   Biohaven Pharmaceutical Holding Company Ltd. Available
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Amyotrophic Lateral Sclerosis Intervention:   Other: no intervention Sponsor:   Ruxandra Iancu Ferfoglia Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease in which ventilatory insufficiency and other respiratory complications account for the majority of deaths. Respiratory failure is a presenting feature in about 3-5% of the patients (de Carvalho et al., 1996).
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Dongchao Shen, Bo Hou, Yinyan Xu, Bo Cui, Pan Peng, Xiaolu Li, Hongfei Tai, Kang Zhang, Shuangwu Liu, Hanhui Fu, Jing Gao, Mingsheng Liu, Feng Feng, Liying Cui
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractNeurological diseases, such as Parkinson ’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional gastrointestinal disorders. These gastrointestinal disturbances may occur at all stages of the neurodegenerative diseases, to such an extent that they are now consi dered an integral part of their clinical picture. Several lines of evidence support the contention that, in central neurodegenerative diseases, changes in gut microbiota and enteric neuro-immune system alterations could contribute to gastrointesinal dysfuncti...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
Patients with amyotrophic lateral sclerosis (ALS) who are hypermetabolic show greater functional decline and shorter survival, according to Australian researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Reka P. Toth, Julie D. Atkin
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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