SOX11 expression as a MRD molecular marker for MCL in comparison with t(11;14) and IGH rearrangement

AbstractThe main cause of death in mantle cell lymphoma (MCL) patients is relapse due to undetermined minimal residual disease (MRD) and therefore monitoring MRD is crucial for making the best treatment decisions. The gold standard method for MRD analysis is the quantitative polymerase chain reaction. The most commonly used molecular markers for measuring MRD in MCL are: t(11;14)(q13;p32) translocation orCCND1 expression and IGH rearrangement. Such markers can, however, be found in other B cell non-Hodgkin lymphomas. Recent studies demonstrate thatSOX11 expression is highly specific for MCL and could be used as a marker for measuring MRD. Moreover, evidence shows thatSOX11 level could be predictive for overall survival (OS) and progression-free survival (PFS). We have measured MRD level in follow-up samples from 27 patients diagnosed with MCL using the molecular markers: t(11;14), IGH rearrangement andSOX11 expression. We compared all markers by their sensitivity, utility and quantitative range. We also examined the predictive value ofSOX11 expression for OS and PFS.SOX11 expression was found to have better specificity, quantitative range and utility than the t(11;14). The predictive value ofSOX11 expression was confirmed. At diagnosis, patients with highSOX11 expression had shorter PFS than patients with lowSOX11 expression (pā€‰=ā€‰0.04*); differences between OS being statistically insignificant. To our best knowledge this is a first study comparingSOX11 with t(11;14) and I...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research