Sensorimotor gating deficits in schizophrenia: Advancing our understanding of the phenotype, its neural circuitry and genetic substrates

In her 1936 report of paired-pulse blink inhibition in 13 Yale undergraduate men, Helen Peak described “quantitative variation in amount of inhibition of the second response incident to changes in intensity of the first stimulus which precedes by different intervals of time” (Peak, 1936). These observations appeared to lay dormant for much of the next 30years, but there was a resurgence of intere st in startle modulation in the 1960's, based primarily on findings from Howard Hoffman's group (e.g.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Guest editorial Source Type: research