Women are 'more likely to donate a kidney than receive one'

Two-thirds of all living kidney donors are altruistic females, research has shown – but it is women who are also more likely to suffer from the most serious stages of chronic kidney disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Agrawal P, Heimbruch KE, Rao S Abstract Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Enhancers regulate gene expression through chromatin loops mediated by architectural proteins such ...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
ConclusionThe removal of protein-bound uremic toxins IS and pCS using DHI or salvianolic acids as protein-bound competitors is superior to previously reported strategies and drugs and may contribute to clinical hemodialysis therapeutic practice.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
In conclusion, we describe one novel mutation, c.1015delG, and a common mutation, c.815_816insGA, of the AGXT gene among four unrelated families with PH1. Moreover, we suggest that the short repeat of the GA dinucleotide may represent a mutation hotspot in the Chinese population. PMID: 30541997 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment. PMID: 30525180 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Authors: Barreto FC, Costa CRVD, Reis LMD, Custódio MR Abstract Renal osteodystrophy (ROD), a group of metabolic bone diseases secondary to chronic kidney disease (CKD), still represents a great challenge to nephrologists. Its management is tailored by the type of bone lesion - of high or low turnover - that cannot be accurately predicted by serum biomarkers of bone remodeling available in daily clinical practice, mainly parathyroid hormone (PTH) and alkaline phosphatase (AP). In view of this limitation, bone biopsy followed by bone quantitative histomorphometry, the gold-standard method for the diagnosis of...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Publication date: Available online 14 December 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Leonardo Spatola, Elena Dozio
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionsMönckeberg medial calcinosis is an incidental finding on panoramic or CBCT imaging. Clinically and radiographically, its importance for the clinician is its strong association with diabetes and chronic kidney disease. The significance of Mönckeberg sclerosis of the infraorbital arteries is unknown. Radiologists and clinicians should be aware of this entity and the importance of documentation of any findings.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: González Sanchidrián S, Labrador Gómez PJ, Aguilar Aguilar JC, Davin Carrero E, Gallego Domínguez S, Gómez-Martino Arroyo JR PMID: 30545713 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
In 1903, the German pathologist Johann M önckeberg described calcifications only affecting the tunica media of medium arteries. The entity was named Mönckeberg arteriosclerosis. Other names in the literature are Mönckeberg sclerosis and Mönckeberg medial calcinosis. The entity is strongly associated with chronic kidney disease and diab etes mellitus. Radiographically, medial calcinosis presents as areas of linear calcifications in soft tissue. The linear calcifications are described as “tram track,” “pipe stem,” “rail track,” or “tram line” when viewed longitudinally.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In conclusion, RSV could alleviate renal damage in obese mice induced by high-fat dietvia suppressing inflammation and oxidative stress.
Source: Inflammation - Category: Allergy & Immunology Source Type: research
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