Women are 'more likely to donate a kidney than receive one'

Two-thirds of all living kidney donors are altruistic females, research has shown – but it is women who are also more likely to suffer from the most serious stages of chronic kidney disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, ART exhibited protective effect on HG-induced HBZY-1 cells by inhibiting the inflammatory response, oxidative stress and ECM accumulation. The TLR4/NF-κB/NLRP3 inflammasome pathway was involved in the protective effect of ART. The results suggested that ART might be a potential therapy agent for the DN treatment.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
ConclusionseGFR markers appear to have relatively low short-term within-person variability, whereas variability in albuminuria appears to be high, making it difficult to distinguish random variability from meaningful biologic changes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Abstract It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague Dawley (SPRD) rats: a control group (CN), 1/2 nephrectomy (N1/2), 2/3 nephrectomy (N2/3), and 5/6 nephrectomy (N5/6). Blood and the kidney cortex were collected to evaluate plasma copeptin concentrations and mRNA expressions of V1a vasopressin receptors (V1aR) and V2 vasopressin receptors (V2...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study investigated whether older adults with chronic kidney disease are at increased risk of falling and serious injury from falls. What factors might contribute to higher risk?Preventing Chronic Disease
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
Publication date: Available online 18 July 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Miyu Nishikawa, Kaori Yasuda, Masashi Takamatsu, Keisuke Abe, Kimie Nakagawa, Naoko Tsugawa, Yoshihisa Hirota, Kazuma Tanaka, Shigeaki Yamashita, Shinichi Ikushiro, Tatsuo Suda, Toshio Okano, Toshiyuki SakakiAbstractWe have reported that 25-hydroxyvitamin D3 [25(OH)D3] binds to vitamin D receptor and exhibits several biological functions directly in vitro. To evaluate the direct effect of 25(OH)D3 in vivo, we used Cyp27b1 knockout (KO) mice, which had no detectable plasma 1α,25-dihydroxyvitamin D...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Authors: Ogunleye A, Akinbodewa AA, Adejumo OA, Oluwafemi TT, Akinfaderin DA Abstract Oxidative stress has been implicated in the pathogenesis, progression of chronic kidney disease (CKD) and development of cardiovascular complications. Hemodialysis (HD) has also been described to contribute significantly to oxidative stress in CKD patients, though reports are conflicting. Objective: We evaluated the effects of one session of HD on the antioxidant capacity and lipid peroxidation in CKD patients. Method: Thirty-six CKD patients requiring HD were recruited into this study. Participants were naïve to HD a...
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et  al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even afte r statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Knowing how chronic kidney disease (CKD) patients talk about their encounters with providers (i.e., their discourse) can inform the important clinical goal of engaging patients in their chronic disease self-ma...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Publication date: Available online 17 July 2018Source: Pharmacological ResearchAuthor(s): Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sánchez-Lozada, José Pedraza-ChaverriAbstractNowadays, chronic kidney disease (CKD) is considered a worldwide public health problem. CKD is a term used to describe a set of pathologies that structurally and functionally affect the kidney, it is mostly characterized by the progressive loss of kidney function. Current therapeutic approaches are insufficient to avoid the development of this disease, which highlights the necessity of developing new strategies to reve...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionIn patients admitted for AHF without renal failure or CKD, WRF with HC is associated with a better prognosis, similar to that of patients without WRF, and should therefore be reclassified as ‘pseudo-WRF’.ResumoIntroduçãoAlterações na função renal com aumento da creatinina têm sido associadas a maior mortalidade em doentes com insuficiência cardíaca aguda (ICA). Já a hemoconcentração na ICA tem-se associado a redução da mortalidade, é também uma causa de elevação da creatinina. Av...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
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