Transient Neonatal Diabetes Mellitus in a Very Preterm Infant due to ABCC8 Mutation

We report the case of a preterm infant with TNDM due to an ABCC8 mutation identified by next-generation sequencing. The pancreatic adenosine triphosphate (ATP)-sensitive K+ (K-ATP) channel is a key regulator of insulin secretion. Gain-of-function mutations in the genes encoding the Kir6.2 (KCNJ11) and SUR1 (ABCC8) subunits of the channel cause neonatal diabetes. The patient was successfully managed with insulin lispro at a 1:100 dilution, drawn up in an insulin pen injector with a 4-mm needle. The insulin lispro dilution allowed administration of the exact insulin doses, obtaining a good glycemic control and minimizing the burden of injections. At 2 months, corrected age insulin doses were progressively decreased until discontinuation. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text

Source: American Journal of Perinatology Reports - March 7, 2018 Category: Perinatology & Neonatology Authors: Piccini, Barbara Coviello, Caterina Drovandi, Livia Rosangela, Artuso Monzali, Francesca Casalini, Emilio Giglio, Sabrina Toni, Sonia Dani, Carlo Tags: Case Report Source Type: research