Imaging agent helps predict success of lung cancer therapy

(Stanford Medicine) Doctors contemplating the best therapy for lung cancer patients may soon be able to predict the efficacy of a widely used lung cancer drug based on an imaging agent and a simple scan, according to the findings of a new clinical trial co-led by researchers at the Stanford University School of Medicine.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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AbstractPurpose of ReviewLung cancer is increasingly a disease of the elderly. Historically, the information on how best to treat these patients is scant, but over recent years, there have been increasing data to support both systemic and targeted treatment as would be offered to younger patients. This paper aims to summarise the considerations behind this.Recent FindingsThe introduction of a screening tool to help understand the overall health of patients will ensure that older cancer patients are considered for all active anti-cancer therapies. These geriatric assessment tools include several important domains such as nu...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
Development and Evaluation of a Novel Drug Delivery: Soluplus®/TPGS Mixed Micelle Loaded With Piperine In Vitro and In Vivo. Drug Dev Ind Pharm. 2018 May 02;:1-20 Authors: Ding Y, Wang C, Wang Y, Xu Y, Zhao J, Gao M, Ding Y, Peng J, Li L Abstract BACKGROUND: Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and TPGS, to improve the aqueous solubility and anti-cancer effect. METHODS: Piperine -loaded mixed micelles were prepared using a thin- film hydration method, and th...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Authors: Zhu N, Qin R, Zhang Q, Fu S, Liu S, Chen Y, Fan J, Han Y Abstract Metronomic chemotherapy in combination with immunotherapy is an attractive approach in cancer therapy. The purpose of the present study was to investigate the anti-tumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with metronomic paclitaxel (MET PTX) on Lewis lung carcinoma transplanted in mice. In the present study, tumor-bearing mice survival time and tumor growth were monitored. The day after the end of the treatment, white blood cells were counted, and the number and maturation of dendritic cell wer...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Abstract BACKGROUND: Patients with advanced cancer often experience muscle wasting (sarcopenia), yet little is known about the characteristics associated with sarcopenia and the relationship between sarcopenia and patients' quality of life (QOL) and mood. MATERIALS AND METHODS: As part of a randomized trial, we assessed baseline QOL (Functional Assessment of Cancer Therapy-General [FACT-G]) and mood (Hospital Anxiety and Depression Scale [HADS]) in patients within 8 weeks of diagnosis of incurable lung or gastrointestinal cancer, and prior to randomization. Using computed tomography scans collected as part of...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
This study demonstrated that coadministration of iRGD resulted in the improvement of the tumor penetration ability of PTX in an in vitro A549 3 D MCS model. In addition, this is the first time a high‐throughput air‐grown lung cancer tumor spheroid model has been developed and evaluated.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Therapy and Prevention Source Type: research
Abstract There are over a dozen of approved cancer drugs, whose administration is tailored to predictive laboratory tests. The examples include estrogen and progesterone receptor status determination for the use of endocrine therapy, HER2 assessment for the administration of HER2-targeting agents, EGFR and ALK gene testing for lung cancer treatment, BRAF analysis in melanoma, etc. While first predictive tests relied on relatively easy laboratory procedures, more recent developments require rather sophisticated assays. For example, administration of PARP inhibitors is tailored to a comprehensive testing of BRCA1 an...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
The frequent use of body computed tomography (CT) scan for unrelated indications and the adoption of low-dose thoracic CT scan for lung cancer screening in high-risk populations have led to a surge of ill-defined pulmonary nodules, many of which require diagnostic and therapeutic resections. Thoracic surgeons play an integral role in selecting the most appropriate approach for tissue acquisition, including transthoracic needle aspirate, transbronchial biopsy with or without the use of navigational bronchoscopy and endobronchial ultrasound, and surgical excisional biopsy.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Editorial commentary Source Type: research
Authors: Roointan A, Sharifi-Rad M, Badrzadeh F, Sharifi-Rad J Abstract Lung cancer is the most common cancer among men. Since the main reason of cancer cells immortality is telomerase activity, targeting of such enzyme can be a promising approach in cancer therapy. Curcumin is a safe and efficient anticancer agent in this context, but its applications in cancer therapy are limited because of its hydrophobic structure and low solubility in water. Today, using nanocarriers for delivery of such anticancer agents is a well performed method. Here, we developed and compared the efficiency of two nanocarriers (PLGA-PEG a...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Treatment Terms Lung cancer Additional SEO Keywords lung cancer, metastatic cancer, metastatic lung cancer, brain metastases, clinical trial, cancer clinical trial, experimental cancer medication, experimental cancer therapy SEO Meta Description Ginger Scott needed new options to treat her metastatic lung cancer. A clinical trial at Duke gave her just that. Author MaryAnn Fletcher Overview Ginger Scott needed new options to treat her metastatic lung cancer. A clinical trial at Duke gave her just that. Hero Image 20160706.scott_.ginger.blog_.01.jpg Preview I...
Source: dukehealth.org: Duke Health News - Category: Consumer Health News Authors: Source Type: news
Conclusions This study evaluated 64Cu-NOTA-YY146 for molecular imaging of CD146 in six human lung cancer cell lines, revealing that tumor accumulation was dependent upon CD146 expression levels. In the future, these imaging agents may be employed for the non-invasive imaging of CD146 positive tumors, allowing for better monitoring of therapeutic response and patient stratification.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology-1 Source Type: research
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