Aggressive Approach to High-Grade Prostate Cancer May Be Best Aggressive Approach to High-Grade Prostate Cancer May Be Best
High-dose radiotherapy plus androgen-deprivation treatment (ADT) delivered superior outcomes compared with standard external-beam radiation and ADT or radical prostatectomy alone.Medscape Medical News
Publication date: Available online 6 April 2020Source: European UrologyAuthor(s): David P. Dearnaley, Daniel R. Saltzstein, John E. Sylvester, Lawrence Karsh, Bryan A. Mehlhaff, Christopher Pieczonka, James L. Bailen, Hongliang Shi, Zhan Ye, Hélène M. Faessel, Huamao Lin, Yanyan Zhu, Fred Saad, David B. MacLean, Neal D. Shore
SpaceOAR© hydrogel rectal dose reduction prediction model: a decision support tool. J Appl Clin Med Phys. 2020 Apr 06;: Authors: Paetkau O, Gagne IM, Alexander A Abstract Prostate cancer external beam radiation therapy can result in toxicity due to organ at risk (OAR) dose, potentially impairing quality of life. A polyethylene glycol-based spacer, SpaceOAR© hydrogel (SOH), implanted between prostate gland and rectum may significantly reduce dose received by the rectum and hence risk of rectal toxicity. SOH implant is not equally effective in all patients. Determining patients in which the im...
To assess the correlation between postimplant dosimetric quantifiers and the genitourinary (GU) toxicity of low-dose rate brachytherapy for prostate cancer.
Abstract INTRODUCTION: To compare the intermediate-term outcomes and patient-reported outcomes (PRO) of robot-assisted laparoscopic prostatectomy (RALP) and radical external beam radiotherapy (RT) in Chinese patients with localised prostate cancer. METHODS: This was a retrospective study performed in patients with localised prostate cancer diagnosed between 2010 and 2011 and treated with either RALP or RT. Information about baseline patient and disease characteristics, post-treatment complications, and latest disease status was retrospectively collected from hospital notes. For assessment of patient-reported ...
Men with Gleason grade Group (GG) 4 and 5 prostate cancer have high failure rates when treated by conventional therapy. We investigated the effect of higher radiation doses on freedom from biochemical failure (FBF) and prostate cancer mortality (cause-specific survival [CSS]) in men treated with a combination of permanent implant and external beam irradiation (EBRT).
High dose-rate (HDR) brachytherapy is commonly administered as a boost to external beam radiation therapy (EBRT). Our purpose was to compare toxicity with increasingly hypofractionated EBRT in combination with a single 15 Gy HDR boost for men with intermediate-risk prostate cancer.
Conclusions: This study highlights excellent outcomes for intermediate-risk prostate cancer patients, including unfavorable intermediate-risk cases, treated with BED ≥ 200 Gy radiotherapy using LDR brachytherapy. LDR alone with a BED of 200 Gy may be an optimal treatment for both favorable and unfavorable intermediate-risk prostate cancer patients, although a longer follow-up is mandatory to confirm the present findings. PMID: 32190064 [PubMed]
Conclusions: The excellent long-term results and low morbidity presented as well as many advantages of prostate brachytherapy over other treatments demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and organ-confined prostate cancer. PMID: 32190063 [PubMed]
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology &RadiotherapyAuthor(s): Gleeson Ian
AbstractUrinary retention and hematuria owing to radiation-induced mucositis are occasional late adverse events in patients with prostate cancer. Moreover, radiation-induced secondary malignancies are late adverse events, although they are extremely rare. Herein, we describe a case of radiation-induced secondary malignancy of the prostate that was initially difficult to distinguish from radiation mucositis. A 74-year-old man with prostate cancer underwent brachytherapy and external beam radiotherapy 9 years ago. Twenty-eight months after irradiation, he presented with urinary retention and hematuria owing to radiation muco...