DNA methylation as a genomic marker of exposure to chemical and environmental agents.

DNA methylation as a genomic marker of exposure to chemical and environmental agents.
Curr Opin Chem Biol. 2018 Mar 02;45:48-56
Authors: Meehan RR, Thomson JP, Lentini A, Nestor CE, Pennings S
Abstract
Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.
PMID: 29505975 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - March 2, 2018 Category: Biochemistry Authors: Meehan RR, Thomson JP, Lentini A, Nestor CE, Pennings S Tags: Curr Opin Chem Biol Source Type: research