Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD ‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis

ConclusionThe altered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated cross‐talk of immune cells and fibroblasts at sites of inflammation and/or fibrosis.

Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder ‐Cappione, Robert Lafyatis, Hans Dooms Tags: Original Article Source Type: research