23andMe granted limited approval for breast cancer risk test

The FDA approved for the first time 23andMe's home test to detect three breast cancer mutations most common in people of Eastern European Jewish descent.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Publication date: Available online 21 July 2018Source: Chinese Chemical LettersAuthor(s): Tianying Yuan, Dan Gao, Shangfu Li, Yuyang JiangAbstractRecapitulating the tumor microenvironment is a major challenge in the development of in vitro tumor model for the study of cancer biology and therapeutic treatments. 3D multicellular tumor spheroids (MCTS) have been used as reliable models of mimicking in vivo solid tumors. Macrophages and extracellular matrix (ECM), regarded as two key factors of the tumor microenvironment, play significant roles in tumor progression and drug resistance. In order to investigate their effects on ...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
In conclusion, miR-519d-3p might be a promising therapeutic strategy against human CRC by directly targeting TROAP. PMID: 30021381 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
This article reviews the effects of DMARDs on the expression and function of P-gp, MRPs, and BCRP and the related molecular mechanism in the treatment of AID. PMID: 30021380 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/β-catenin signaling pathway. Biomed Pharmacother. 2018 Sep;105:848-855 Authors: Yang WH, Ding MJ, Cui GZ, Yang M, Dai DL Abstract Despite significant progress in the treatment of breast cancer due to advances in surgery, cytotoxic agents, and endocrine therapy, the prognosis for patients has not improved much. Accumulated evidence indicates that heterogeneous nuclear ribonucleoprotein M (hnRNPM) and Wnt/β-catenin function as tumor oncogenes in the progression of many cancers. The presen...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Abstract Despite advances in cancer treatment, breast cancer remains one of the main life threatening diseases in women. Most anti-breast cancer drugs cause severe health complications and multidrug resistance. Although, some natural products, such as hesperidin (Hes), piperine (Pip) and bee venom (BV), showed anti-breast cancer effect when used separately, their combined effect together or with the anti-cancer drug tamoxifen (Tam) has not yet been studied. Herein, we hypothesized that these three natural products could potentiate the therapeutic effect of Tam when used together. First, we studied the cytotoxic ef...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Conclusion: Twice-yearly treatment with denosumab was associated with increased BMD among Japanese women receiving adjuvant AI therapy, regardless of the baseline characteristics or skeletal site. PMID: 30022834 [PubMed]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Ther Clin Risk Manag Source Type: research
Publication date: Available online 20 July 2018Source: Diagnostic and Interventional ImagingAuthor(s): P. Kong, L. Chen, X. Shi, H. Pan, M. Yu, H. Ge, J. Zhu, G. Ma, L. Li, Q. Ding, W. Zhou, S. WangAbstractPurposeTo evaluate the mechanism for enhancing cell death induced by microwave ablation (MWA) combined with doxorubicin treatment in breast cancer cells.Materials and methodsDifferent temperatures of heat treatment were used to mimic the tumor affected by sublethal heat during MWA in vitro. Breast cancer cells were treated at 43 °C and 45 °C, with or without doxorubicin. Cell viability, apoptosis, and i...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Yasaman Sadat Borghei, Morteza Hosseini, Mohammad Reza GanjaliAbstractMicroRNAs as regulators play an important role in gene expression and subsequently in various diseases. Newly, some studies show that up-regulation of miR-155 has been described in several types of human tumors. Due to the high importance of detecting miRNA with both fast speed and high sensitivity and the fundamental role of miR-155 in the breast cancer, we proposed a new miRNA detection method relying on photocatalytic activity of Cysteine capped gold nano...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
ConclusionsUltrasound evaluation may be the first level exam in case of suspicious symptomatic breast implant rupture. Importantly, our results demonstrate that magnetic resonance imaging could be avoided in all those cases where an extracapsular rupture has been diagnosed using ultrasound.Level of Evidence: Level IV, diagnostic study.
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
AbstractPurpose of ReviewMeasurement of the quality of cancer care is foundational to quality improvement, and widely pursued in high-income countries. However, cancer care quality measurement has not yet been systematically attempted in low-income countries (LICs). We aimed to describe key considerations in developing quality measures for breast cancer care in LICs, and explore challenges and next steps.Recent FindingsThere are no published reports of systematically developed quality measures from LICs, and few reports of care quality. However, existing resource-stratified treatment guidelines can help facilitate measure ...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
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