Hypothyroidism linked to higher risk of fistula after neck surgery
Patients with low thyroid function have an increased risk of suffering complications after surgery, a study in theAnnals of Surgical Oncology suggests.Newswise
In conclusion, although the authors recognize the limitations of their study, we believe that it is important to stress the necessity of extending the follow-up post LT4 cessation beyond 8 weeks and having a second TSH measurement at least 12-16 weeks post LT4-cessation before characterizing a subject as euthyroid or hypothyroid. PMID: 31007136 [PubMed - as supplied by publisher]
Marco Vacante1, Antonio Biondi1, Francesco Basile1, Roberto Ciuni1, Salvatore Luca1, Salomone Di Saverio2, Carola Buscemi3, Enzo Saretto Dante Vicari3 and Antonio Maria Borzì3* 1Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy 2Cambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom 3Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy There is a high prevalence of hypothyroidism in the elderly population, mainly among women. The mo...
We highly appreciated the long term study by Moon et al. on the substantial increased risk of ischemic cerebrovascular and cardiac events among individuals younger than 65 years old with subclinical hypothyroidism (SCH)1. We wish to draw the attention to a curable mechanism driving this association, i.e. the infection by pathogenic strains of Helicobacter pylori. Such organisms are marked by the production of the cytotoxin-associated gene A protein (CagA) and are endowed with an increased inflammatory potential.
CONCLUSIONS: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions. PMID: 31002146 [PubMed - in process]
Authors: Soundaram V, Ramesh Bhat Y,2*, Lewis LE, Girisha KM, Jayashree P, Balasubramanian S, Pratyusha R Abstract Pfeiffer syndrome is a rare genetic disorder with combination of bicoronal craniosynostosis, broad thumbs, broad great toes, ankylosis of elbow and partial variable syndactyly of the hands and feet. Since the disorder was reported by Pfeiffer in 1964, new associations have been added on. Authors report a newborn with features of Pfeiffer syndrome type 3 with hypothyroidism, tail like appendage and extremely anteriorly placed anus as new associations. PMID: 30992743 [PubMed]
ConclusionPatients with subclinical hypothyroidism versus healthy individuals had some changes in echocardiographic parameters that indicate involvement of diastolic function of the left ventricle. They were significantly different when compared SH group and the control group. This study demonstrated ventricle diastolic dysfunction in pediatric patients with hypothyroidism. The results of our study suggest that cardiac follow-up may be useful in patients with subclinical hypothyroidism and clinical trials are needed to explore therapeutic effects of T4 and T3 administration in this patients.
Publication date: Available online 17 April 2019Source: Molecular and Cellular EndocrinologyAuthor(s): C.M. López Fontana, G. Pennachio, L. Zyla, J. Toneatto, F.A. Bruna, N. Ortiz, P.L. Sassi, F.E. Santiano, S. García, C.V. Sasso, E. Pietrobon, G.A. Jahn, V. Pistone Creydt, M. Soaje, R.W. CarónAbstractTo characterize the influence of hypothyroidism on the endocrine activity of mesenteric and omental adipose tissue (MOAT) and the peripheral regulation of energy balance (EB) in rats, we analyzed food intake (FI); basal metabolic rate (BMR); locomotor activity; body weight (BW); serum hormone concentratio...
In a recent opinion article, published in Hormones-International Journal of Endocrinology and Metabolism, an endocrinologist theorises that Mona Lisa may have suffered from severe hypothyroidism.Medical Xpress
In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).
Conclusion: This case demonstrates a typical presentation of anti-NMDA-R encephalitis, as well as the challenges that can delay diagnosis. Symptoms vary and are often psychiatric, making these patients difficult to diagnose clinically, and they therefore require thorough investigation. This case illustrates the necessity to be inquisitive and to challenge the diagnosis when a clinical picture is not congruent because an accurate diagnosis is imperative in guiding appropriate treatment. PMID: 30983904 [PubMed]