OBIT: Dr. Isabelle Rapin

Isabelle Rapin, Who Advanced Concept of an Autism Spectrum, Dies at 89 By Richard SandomirThe New York Times09 June 2017Article
Source: BrainBlog - Category: Neurology Source Type: blogs

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Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Jessica A. Burket, Jerrah C. Pickle, Allison M. Rusk, Bronson A. Haynes, Julia A. Sharp, Stephen I. DeutschAbstractStress reactivity and glucocorticoid signaling alterations are reported in mouse models of autism spectrum disorder (ASD). Balb/c mice display decreased locomotor activity in the presence of stimulus mice and spend less time exploring enclosed stimulus mice; this mouse strain has been validated as an ASD model. VU0410120, a glycine type 1 transporter (GlyT1) inhibitor, improved soc...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
In conclusion, despite contrasting neurochemical profiles, partial glycine site agonists and glycine reuptake inhibitors exhibit comparable pro-cognitive effects in rats of poten tial relevance to treatment of schizophrenia and other brain disorders where cognitive performance is impaired.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
This study aimed to investigate the relationship between parent and child anxiety levels and child autism characteristics on the four domains of family accommodation; Participation, Modification, Distress, and Consequence. A community sample (n = 132) of parents of children on the spectrum completed questionnaires on their child’s autism characteristics and anxiety symptomatology as well as their own levels of anxiety and family accommodation behaviours. Regression models identified specific aspects of child anxiety as well as parent anxiety as predictive of family accommodation, with the child’s ...
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 17 January 2020Source: Neurochemistry InternationalAuthor(s): Pamela R. Westmark, Alejandra Gutierrez, Aaron K. Gholston, Taralyn M. Wilmer, Cara J. WestmarkAbstractThe ketogenic diet is highly effective at attenuating seizures in refractory epilepsy and accumulating evidence in the literature suggests that it may be beneficial in autism. To our knowledge, no one has studied the ketogenic diet in any fragile X syndrome (FXS) model. FXS is the leading known genetic cause of autism. Herein, we tested the effects of chronic ketogenic diet treatment on seizures, body weight, ketone and glucos...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Publication date: Available online 17 January 2020Source: NeuroImage: ClinicalAuthor(s): Sukrit Gupta, Jagath C. Rajapakse, Roy E. WelschAbstractFunctional modules in the human brain support its drive for specialization whereas brain hubs act as focal points for information integration. Brain hubs are brain regions that have a large number of both within and between module connections. We argue that weak connections in brain functional networks lead to misclassification of brain regions as hubs. In order to resolve this, we propose a new measure called ambivert degree that considers the node’s degree as well as conne...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 17 January 2020Source: NeuroImage: ClinicalAuthor(s): Mladen Rakić, Mariano Cabezas, Kaisar Kushibar, Arnau Oliver, Xavier LladóAbstractAutism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detection of common patterns in autism subjects versus typical controls for classification purposes. In this work, we propose a method for t...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Autism Spectrum Conditions (ASC) can be reliably diagnosed by 24  months of age. However, despite the well-known benefits of early intervention, there is still a research-practice gap in the timely identificati...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Study protocol Source Type: research
In a prominent “USA Today” op-ed—featured in the newspaper’s online Opinion section and reprinted by publications all over the country—ASHA 2020 President Theresa Rodgers addresses adults’ digital usage habits. Rodgers writes about how parents’ preoccupation with smartphones can negatively affect their children’s speech and language development. Parents’ diverted attention deprives children of essential day-to-day human interaction. This crucial early interaction fuels language development and communication skills. In the piece, Rodgers writes: “But anyone raising...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Advocacy Audiology News Slider Speech-Language Pathology Autism Spectrum Disorder Early Intervention Language Disorders social skills Speech Disorders Source Type: blogs
In 2019, 84% of Americans think vaccinating children is important, down from 94% in 2001; 10% still believe vaccines can cause autism, according to a new Gallup survey.Medscape Medical News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01478
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
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