Determinant factors for chronic kidney disease after partial nephrectomy
(Rapamycin Press) Minimally invasive surgery appears to offer broader therapeutic scope for the renal masses without compromising oncological outcomes in proper hands.
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR)
Conclusion: Taken together, reduced nephron mass have a negative effect on the repair process that is partially mediated by the disruption of the cell cycle regulation.Nephron
CONCLUSIONS: The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy. PMID: 29616601 [PubMed - in process]
Nephrons loss due to surgery for kidney cancer increases the risk of chronic kidney disease and has several sequelae that may compromise patient general health status. Previous investigations observed lower cardiovascular events after nephron-sparing surgery [NSS] relative to radical nephrectomy [RN]. The aim of the study is to investigate the effect of NSS on each specific cardiovascular category taking into account the temporal pattern of presentation.
Kidney function variability has been associated with worse renal outcomes for patients with chronic kidney disease (CKD). We sought to determine if variability in preoperative kidney function was associated with development of significant CKD and overall survival following radical and partial nephrectomy in a large integrated health care system.
Partial nephrectomy (PN) for clinically localized renal cell carcinoma (CLRCC) allows for comparable oncologic benefit to radical nephrectomy with improved preservation of renal function in pT1-T2 masses. The decreased impact on GFR in patients within normal or near normal renal function is less important than the change observed in those patients with chronic kidney disease (CKD). We aimed to investigate the rates and risk factors for CKD upstaging after PN in patients with normal and at-risk kidneys, and to understand how surgically modifiable factors influence that relationship.
Ischemia and parenchymal loss during partial nephrectomy may result in worsening of existing chronic kidney disease (CKD). There is inconclusive evidence regarding the benefit of non-main arterial clamping (non-MAC) in patients with CKD. We sought to analyze whether non-MAC techniques are associated with a renal functional benefit in patients with stage III-V CKD.
Acute Kidney Injury (AKI) is a common occurrence after partial nephrectomy (PN) and is a significant risk factor for chronic kidney disease. We therefore sought to create a model that predicts AKI at discharge in patients undergoing robot-assisted partial nephrectomy (RAPN).
Though radical cytoreductive nephrectomy has been shown to improve overall survival in patients with metastatic renal cell carcinoma, the impact this treatment has on renal function has not been adequately assessed. Radical nephrectomy in patients with localized cancer has been associated with risk of chronic kidney disease development. Using patients enrolled in ADAPT trial that received cytoreductive nephrectomy in the metastatic setting, we intend to study the effect of this procedure on overall renal function in patients without kidney disease.
Retrospective studies suggest that partial nephrectomy (PN) provides improved survival compared to radical nephrectomy (RN), even when performed electively. However, selection bias may be contributing and further investigation is required. We evaluated factors associated with non-renal cancer-related survival (NRCS) after PN or RN for patients with preoperative GFR ≥60ml/min/1.73m2.