A selective phosphodiesterase 10A inhibitor reduces l ‐dopa‐induced dyskinesias in parkinsonian monkeys

ConclusionsResults show that regulation of striatal cyclic nucleotides by phosphodiesterase 10A inhibition could be a useful therapeutic approach for l‐dopa‐induced dyskinesia, and therefore data support further studies of selective phosphodiesterase 10A inhibitors for PD therapy. © 2018 International Parkinson and Movement Disorder Society

Source: Movement Disorders - March 6, 2018 Category: Neurology Authors: Goichi Beck, Shunsuke Maehara, Phat Ly Chang, Stella M. Papa Tags: Research Article Source Type: research