X-linked chronic granulomatous disease in a female carrier with novel pathogenic mutation and skewed X-inactivation

The patient is a 17-year-old girl referred to our primary immunodeficiency consult service after the diagnosis of a complicated left deltoid abscess due to Salmonella Typhimurium. Three months earlier she had noticed a stiff lesion in the left upper arm similar to an insect sting, which was diagnosed as cellulitis and treated with oral flucloxacillin for 8 days. Two weeks later she presented with fever and a local abscess. The abscess was drained and treated with oral amoxicillin-clavulanic acid.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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In this study, UV photolysis was selected as an appropriate pretreatment technology for antibiotic-containing wastewater. It could decompose many kinds of antibiotics and was not inhibited by the coexisting organics in wastewater. The antibacterial activities of five kinds of antibiotics, which were eliminated with UV irradiation, exhibited a significantly positive correlation with their parent compound concentrations. The photodecomposition of the main functional groups in antibiotics contributed to the elimination of antibacterial activity. Defluorination was the main pathway to eliminate the antibacterial activity of an...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
AbstractThis guideline aims to describe the complement system and the functions of the constituent pathways, with  particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical, alternative and lectin pathways, which converge with the cleavage of central C3. Complement deficiencies account for ~5% of PIDs. The clinical consequences of inherited defects in the complement system...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsAmong uninsured and underinsured asthma patients with GAD and/or MDD who were initiated on a single antidepressant, those who were titrated to achieve target doses had reduced risk of severe asthma exacerbations and lower number of asthma ‐related outcomes than those who were not optimized to achieve target doses.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Authors: Meyer D, Smit DP Abstract Both infective and neoplastic eyelid and orbital conditions in human immunodeficiency virus (HIV) infected patients are often the result of opportunistic or co-infections (OI). In most cases, these clinical findings in younger patients alert the physician to suspected underlying HIV infection. When the eyelids and periorbital skin are primarily involved in OI with varicella-zoster virus it is called Herpes Zoster Ophthalmicus. Co-infection with a Pox virus manifests as molluscum contagiosum eruptions. Orbital cellulitis is secondary to various organisms (Mycobacterium tuberculosis...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: Available online 15 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Michelle Lierl, Amal Assa’ad, Jennifer Jennings, Michael Farrell, William D. Hardie
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Samantha Platt, Scott H. Sicherer
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): J.H. Hull, Krystelle Godbout, Louis-Philippe BouletAbstractBreathlessness during sport can be caused by a variety of cardiorespiratory conditions, but when associated with stridor, usually arises from an upper airway etiology. The term exercise-induced laryngeal obstruction (EILO) is now used to describe the phenomonen of transient glottic closure occurring in association with physical activity.Exercise related laryngeal closure is most commonly encountered in athletic individuals and likely affe...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsOur results identify specialty specific concerns and can be used to inform the development of tailored interventions to improve wellness and minimize burnout. However, future surveys with a larger sample size are needed to obtain a more robust data set on allergy and immunology specific wellness challenges.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Doyen V, Casset A, Divaret-Chauveau A, Khayath N, Peiffer G, Bonniaud P, Dalphin JC, De Blay F Abstract Allergy is a hypersensitivity reaction induced by immunological mechanisms. In asthma, allergy has a complex role and is usually IgE mediated. Allergy must be evaluated during the work up but evidence of IgE sensitivity does not mean that allergens play a role in the pathophysiology of the disease. The clinical relevance of the sensitivity has to be considered. This paper describes current available tools to screen for IgE sensitivity, allergen exposure and their role in asthma. PMID: 32057505 [PubMe...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
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